Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

被引：27
|
作者：
Wang, Xiyue [1 ]
Hu, Qingyun [1 ]
Tang, Hui [1 ]
Pan, Xinhui [1 ]
机构：
[1] Shihezi Univ, Sch Pharmaceut Sci, Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Shihezi 832002, Peoples R China
来源：
PHARMACEUTICALS | 2023年 / 16卷 / 02期
基金：
中国国家自然科学基金;
关键词：
isoxazole; isoxazoline; natural products; pharmacological activity; structure-activity relationship; IN-VITRO; ANTIOXIDANT ACTIVITY; ANTICANCER ACTIVITY; OLEANOLIC ACID; ANTI-ALZHEIMER; CELL-CYCLE; DERIVATIVES; ISOXAZOLINE; POTENT; RING;
D O I：
10.3390/ph16020228
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. Over 80 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antidiabetic, cardiovascular, and other activities, were reviewed. A review of recent studies on the use of isoxazoles and isoxazolines moiety derivative activities for natural products is presented here, focusing on the parameters that affect the bioactivity of these compounds.
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页数：35
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