Isoxazole/Isoxazoline Skeleton in the Structural Modification of Natural Products: A Review

被引:27
|
作者
Wang, Xiyue [1 ]
Hu, Qingyun [1 ]
Tang, Hui [1 ]
Pan, Xinhui [1 ]
机构
[1] Shihezi Univ, Sch Pharmaceut Sci, Lab Xinjiang Phytomed Resource & Utilizat, Minist Educ, Shihezi 832002, Peoples R China
基金
中国国家自然科学基金;
关键词
isoxazole; isoxazoline; natural products; pharmacological activity; structure-activity relationship; IN-VITRO; ANTIOXIDANT ACTIVITY; ANTICANCER ACTIVITY; OLEANOLIC ACID; ANTI-ALZHEIMER; CELL-CYCLE; DERIVATIVES; ISOXAZOLINE; POTENT; RING;
D O I
10.3390/ph16020228
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Isoxazoles and isoxazolines are five-membered heterocyclic molecules containing nitrogen and oxygen. Isoxazole and isoxazoline are the most popular heterocyclic compounds for developing novel drug candidates. Over 80 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antidiabetic, cardiovascular, and other activities, were reviewed. A review of recent studies on the use of isoxazoles and isoxazolines moiety derivative activities for natural products is presented here, focusing on the parameters that affect the bioactivity of these compounds.
引用
收藏
页数:35
相关论文
共 50 条
  • [1] Piperazine skeleton in the structural modification of natural products: a review
    Zhang, Run-Hui
    Guo, Hong-Yan
    Deng, Hao
    Li, Jinzi
    Quan, Zhe-Shan
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 1165 - 1197
  • [2] Isoxazoline containing natural products as anticancer agents: A review
    Kaur, Kamalneet
    Kumar, Vinod
    Sharma, Anil Kumar
    Gupta, Girish Kumar
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 77 : 121 - 133
  • [3] Application of cinnamic acid in the structural modification of natural products: A review
    Deng, Hao
    Xu, Qian
    Guo, Hong-Yan
    Huang, Xing
    Chen, Fener
    Jin, Lili
    Quan, Zhe-Shan
    Shen, Qing-Kun
    PHYTOCHEMISTRY, 2023, 206
  • [4] Application of Amino Acids in the Structural Modification of Natural Products: A Review
    Xu, Qian
    Deng, Hao
    Li, Xiaoting
    Quan, Zhe-Shan
    FRONTIERS IN CHEMISTRY, 2021, 9
  • [5] Application of 18β-glycyrrhetinic acid in the structural modification of natural products: a review
    Li, Wan-Xin
    Lu, Ye-Fang
    Wang, Fei
    Ai, Bing
    Jin, Sheng-Bo
    Li, Siqi
    Xu, Guang-Hua
    Jin, Cheng-Hua
    MOLECULAR DIVERSITY, 2025, 29 (01) : 739 - 781
  • [6] Enzymatic structural modification of natural products
    Jiang, ZY
    Xu, SW
    Wu, H
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2002, 22 (03) : 220 - 226
  • [7] Synthesis of Oxazole, Oxazoline and Isoxazoline Derived Marine Natural Products: A Review
    Tilvi, Supriya
    Singh, Keisham S.
    CURRENT ORGANIC CHEMISTRY, 2016, 20 (08) : 898 - 929
  • [8] Natural products-isoxazole hybrids: A review of developments in medicinal chemistry
    Wang, Jin
    Wang, Dong-Bo
    Sui, Li -Li
    Luan, Tian
    ARABIAN JOURNAL OF CHEMISTRY, 2024, 17 (06)
  • [9] Synthesis and Structural Modification of Marine Natural Products
    Zhang, Juan
    Zhang, Hua
    Alexandre Muehlmann, Luis
    Jiang, Cheng-Shi
    Guo, Yue-Wei
    MOLECULES, 2017, 22 (06)
  • [10] Application of triazoles in the structural modification of natural products
    Guo, Hong-Yan
    Chen, Zheng-Ai
    Shen, Qing-Kun
    Quan, Zhe-Shan
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2021, 36 (01) : 1115 - 1144