Lewis Acid-Promoted Three-Component Cyclization for the Construction of Functionalized Oxazoles

被引：10
|
作者：
Li, Anquan [1 ,2 ]
Zhao, Jun [1 ,2 ]
Zhang, Chen [1 ,2 ]
Jiang, Qiuxia [1 ,2 ]
Zhu, Baofu [1 ,2 ]
Cao, Hua [1 ,2 ]
机构：
[1] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China
[2] Guangdong Pharmaceut Univ, Guangdong Cosmet Engn & Technol Res Ctr, Zhongshan 528458, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 01期
关键词：
VINYL SULFONES; PROPARGYLIC AMIDES; BOND FORMATION; C-S; ACCESS; SULFONYLATION; INHIBITORS; ASCIDIANS; DISCOVERY; AGENTS;
D O I：
10.1021/acs.joc.2c01432
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient synthetic strategy from amides, ynals, and sodium sulfinates via a Lewis acid-promoted threecomponent reaction has been reported. Thus, a broad range of various aryl (not alkyl)-substituted oxazoles could be synthesized via the formation of C-N, C-O, and C-S bonds in a one-pot process. In addition, this reaction possesses other unique advantages, such as transition metal-free catalysis, high step economy, good functional group tolerance, and good regioselectivity.
引用
收藏
页码：27 / 38
页数：12
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