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Natl Univ Hlth Syst, Natl Univ Hosp, Univ Med Cluster, Div Resp & Crit Care Med, 1E Kent Ridge Rd,NUHS Tower Block Level 10, Singapore 119228, Singapore Natl Univ Hlth Syst, Natl Univ Hosp, Univ Med Cluster, Div Resp & Crit Care Med, 1E Kent Ridge Rd,NUHS Tower Block Level 10, Singapore 119228, Singapore