Heating tumors with tumor cell-derived nanoparticles to enhance chemoimmunotherapy for colorectal cancer

被引：1
|
作者：
Li, Xin-Ying [1 ,2 ]
Li, Rong-Hui [1 ]
Cong, Jun-Zi [3 ]
Liu, Wen-Shang [2 ]
Zhang, Yang [1 ]
Guan, Hui-Lin [4 ]
Zhu, Ling-Ling [5 ]
Chen, Kai [1 ]
Pang, Li-Ying [1 ]
Jin, Hong [1 ]
机构：
[1] Mudanjiang Med Univ, Affiliated Hongqi Hosp, Dept Clin Lab, Mudanjiang 157011, Peoples R China
[2] Naval Med Univ, Changhai Hosp, Dept Lab & Diag, Shanghai 200433, Peoples R China
[3] Mudanjiang Med Univ, Affiliated Hongqi Hosp, Dept Sci Res, Mudanjiang 157011, Peoples R China
[4] Mudanjiang Med Univ, Dept Sci Res, Mudanjiang 157011, Peoples R China
[5] Mudanjiang Med Univ, Affiliated Hongqi Hosp, Dept Hematol, Mudanjiang 157011, Peoples R China
来源：
NANOMEDICINE | 2024年 / 19卷 / 07期
关键词：
biomimetic nanobiomaterials; chemoimmunotherapy; colorectal cancer; immunogenic cell death; EXTRACELLULAR VESICLES; DOXORUBICIN; DELIVERY; DEATH; STRESS;
D O I：
10.2217/nnm-2023-0332
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim: To investigate the mechanism of doxorubicin (DOX)-induced immunogenic cell death (ICD) and to improve immunotherapy efficacy. Materials & methods: In this study, hybrid vesicles containing DOX (HV-DOX) were prepared by thin-film hydration with extrusion, and the formulated nanoparticles were characterized physically. Furthermore, in vitro experiments and animal models were used to investigate the efficacy and new mechanisms of chemotherapy combined with immunotherapy. Results: DOX improved tumor immunogenicity by alkalinizing lysosomes, inhibiting tumor cell autophagy and inducing ICD. HVs could activate dendritic cell maturation, synergistically enhancing chemotherapeutic immunity. Conclusion: The mechanism of DOX-induced ICD was explored, and antitumor immunity was synergistically activated by HV-DOX to improve chemotherapeutic drug loading and provide relevant antigenic information.
引用
收藏
页码：561 / 579
页数：19
相关论文
共 50 条
  • [31] Stromal cell-derived factor (SDF)-1 promotes cell migration and tumor growth of colorectal metastasis
    Kollmar, O.
    Rupertus, K.
    Scheuer, C.
    Junker, B.
    Tilton, B.
    Schilling, M. K.
    Menger, M. D.
    ONKOLOGIE, 2008, 31 : 56 - 57
  • [32] Stromal cell-derived factor-1 promotes cell migration and tumor growth of colorectal metastasis
    Kollmar, Otto
    Rupertus, Kathrin
    Scheuer, Claudia
    Junker, Bastian
    Tilton, Bettina
    Schilling, Martin K.
    Menger, Michael D.
    NEOPLASIA, 2007, 9 (10): : 862 - 870
  • [33] STRATEGIES TO ENHANCE AND ACCELERATE THE PRODUCTION OF CELL-DERIVED MATRICES
    Zeugolis, Dimitrios
    TISSUE ENGINEERING PART A, 2022, 28 : S28 - S28
  • [34] NK cell-derived exosomes enhance the anti-tumor effects against ovarian cancer by delivering cisplatin and reactivating NK cell functions
    Luo, Heyong
    Zhou, Yanhua
    Zhang, Jing
    Zhang, Yingchun
    Long, Shiqi
    Lin, Xiaojin
    Yang, Anqing
    Duan, Jiangyao
    Yang, Na
    Yang, Zhiru
    Che, Qiyuan
    Yang, Yuxin
    Guo, Ting
    Zi, Dan
    Ouyang, Weiwei
    Yang, Wei
    Zeng, Zhu
    Zhao, Xing
    FRONTIERS IN IMMUNOLOGY, 2023, 13
  • [35] Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression
    Xinyi Gao
    Shiqi Zhou
    Zhaofu Qin
    Dechuan Li
    Yuping Zhu
    Dening Ma
    Journal of Translational Medicine, 21
  • [36] Upregulation of HMGB1 in tumor-associated macrophages induced by tumor cell-derived lactate further promotes colorectal cancer progression
    Gao, Xinyi
    Zhou, Shiqi
    Qin, Zhaofu
    Li, Dechuan
    Zhu, Yuping
    Ma, Dening
    JOURNAL OF TRANSLATIONAL MEDICINE, 2023, 21 (01)
  • [37] Multiple myeloma cell-derived microvesicles are enriched in CD147 expression and enhance tumor cell proliferation
    Arendt, Bonnie K.
    Walters, Denise K.
    Wu, Xiaosheng
    Tschumper, Renee C.
    Jelinek, Diane F.
    ONCOTARGET, 2014, 5 (14) : 5686 - 5699
  • [38] Transfer of microRNA-25 by colorectal cancer cell-derived extracellular vesicles facilitates colorectal cancer development and metastasis
    Wang, Shanchao
    Zhang, Zeyan
    Gao, Qianfu
    MOLECULAR THERAPY-NUCLEIC ACIDS, 2021, 23 : 552 - 564
  • [39] Ferrimagnetic Nanoparticles Enhance Microwave Heating for Tumor Hyperthermia Therapy
    Pearce, John A.
    Cook, Jason R.
    Emelianov, Stanislav Y.
    2010 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2010, : 2751 - 2754
  • [40] Impact of Tumor Vascularity on Responsiveness to Antiangiogenesis in a Prostate Cancer Stem Cell-Derived Tumor Model
    Zhang, Kexiong
    Waxman, David J.
    MOLECULAR CANCER THERAPEUTICS, 2013, 12 (05) : 787 - 798
12345