Synthesis and properties of novel type I photosensitizer polycyclic amide

被引：3

作者：

Wang, Kui ^{[1
]}

Ye, Tao ^{[1
]}

Du, Haoyang ^{[1
]}

Jin, Xiangyu ^{[1
]}

Yi, Xiaofen ^{[1
]}

Gao, Huiying ^{[1
]}

Zhang, Yuan ^{[1
]}

Dong, Wei ^{[1
]}

Liu, Shihui ^{[2
]}

Guan, Jing ^{[1
]}

Lin, Feng ^{[1
]}

Xia, Debin ^{[2
,3
]}

机构：

[1] Harbin Med Univ, Coll Pharm, Dept Organ Chem, Harbin, Peoples R China

[2] Harbin Inst Technol, Sch Chem & Chem Engn, MIIT Key Lab Crit Mat Technol New Energy Convers &, Harbin, Peoples R China

[3] Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin, Peoples R China

来源：

NANOSCALE ADVANCES | 2023年 / 5卷 / 14期

基金：

中国国家自然科学基金;

关键词：

PHOTODYNAMIC THERAPY; TUMOR; MODEL;

D O I：

10.1039/d3na00341h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we have designed and synthesized a novel type-I photosensitizer (PhPA) via Rh-catalyzed oxidative cyclization of diacetoxyterephthalamide with alkynes. The photoelectric properties, photosensitivity and photodegradation process of PhPA have been systematically investigated. The remarkable fluorescence quenching effect (& phi;(PL) < 0.01) of PhPA suggests that the intersystem crossing from the singlet excited state to the reactive triplet state is enhanced by the enlarged conjugated backbone. Additionally, the ability of superoxide radical (O-2(-)) generation was confirmed by electron paramagnetic resonance spectroscopy. Finally, the mechanism of PhPA photo-oxidative degradation via the structure of two metabolites is proposed.

引用

页码：3629 / 3633

页数：5

共 50 条

[31] Collagen type I amide I band infrared spectroscopy
Vidal, Benedicto de Campos
Mello, Maria Luiza S.
MICRON, 2011, 42 (03) : 283 - 289
[32] Versatile synthesis of novel polycyclic ligands
Nozari, Mohammad
Johnson, Noah
Ji, Haifeng
Addison, Anthony
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
[33] Novel polycyclic thiones: Synthesis and complexation
Tapu, Daniela
Hooper, Reagan
Kuykendall, Orrion
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
[34] A novel and practical synthesis of polycyclic fluoranthenes
Cho, B. P.
Tetrahedron Letters, 36 (14):
[35] A NOVEL AND PRACTICAL SYNTHESIS OF POLYCYCLIC FLUORANTHENES
CHO, BP
TETRAHEDRON LETTERS, 1995, 36 (14) : 2403 - 2406
[36] Photopolymerization of hyperbranched aliphatic acrylated poly(amide ester). I. Synthesis and properties
Lin, D
Shi, WF
Nie, KM
Zhang, YC
JOURNAL OF APPLIED POLYMER SCIENCE, 2001, 82 (07) : 1630 - 1636
[37] PROPERTIES AND FUNCTIONS OF THE NOVEL TYPE I INTERFERON EPSILON
Marks, Zoe R. C.
Campbell, Nicole
deWeerd, Nicole A.
Lim, San S.
Gearing, Linden J.
Bourke, Nollaig M.
Hertzog, Paul J.
SEMINARS IN IMMUNOLOGY, 2019, 43
[38] SYNTHESIS OF NOVEL POLYCYCLIC NUCLEOSIDE ANALOGS
BISCHOFBERGER, N
MATTEUCCI, MD
NUCLEOSIDES & NUCLEOTIDES, 1989, 8 (5-6): : 859 - 862
[39] SYNTHESIS OF NOVEL POLYCYCLIC SELENEPINONE COMPOUNDS
SAKAKIBARA, M
MIZUMOTO, T
WATANABE, Y
TORU, T
UENO, Y
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1992, 65 (07) : 1794 - 1798
[40] THE SYNTHESIS OF SOME NOVEL POLYCYCLIC CHROMANS
AUKRUST, IR
BAKSTAD, E
SKATTEBOL, L
ACTA CHEMICA SCANDINAVICA, 1993, 47 (03): : 314 - 317

← 1 2 3 4 5 →