Phosphonylacylation of Alkenes Enabled by Visible-Light-Induced N-Heterocyclic Carbene Catalysis

被引：3
|
作者：
Jin, Ming-Lei [1 ,2 ]
Dong, Yi-Xiong [1 ,2 ]
Gao, Zhong-Hua [1 ,2 ]
Ye, Song [1 ,2 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 08期
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1021/acs.orglett.4c00242
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report the phosphonylacylation of alkenes via visible-light-induced N-heterocyclic carbene (NHC) catalysis to afford a series of gamma-ketophosphonates in moderate to good yields. This protocol features mild conditions, free of photocatalyst, and good compatibility of functional groups. The excited Breslow enolate intermediate was proposed to undergo single-electron transfer with oxime phosphonate to generate the corresponding ketyl radical and phosphonyl radical.
引用
收藏
页码：1711 / 1717
页数：7
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