[bmim]BF4-accelarated One-pot Synthesis of 2-amino Thiazole Derivatives

被引：1

作者：

Duc, Dau Xuan ^{[1
]}

Chung, Nguyen Thi ^{[1
]}

机构：

[1] Vinh Univ, Sch Educ, Dept Chem, Vinh City, Vietnam

来源：

LETTERS IN ORGANIC CHEMISTRY | 2023年 / 20卷 / 08期

关键词：

Ionic liquid; thioureas; NBS; aryl ketones; heterocyclic compounds; thioamides; 2,4-DISUBSTITUTED THIAZOLES; EFFICIENT SYNTHESIS; CATALYST; OXAZOLES;

D O I：

10.2174/1570178620666230207093953

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and environmentally-friendly protocol for the synthesis of 2- (arylamino)thiazoles has been investigated. The two-step, three-component reaction of aryl ketones, N-bromosuccinimide, and thiourea derivatives was performed using [bmim][BF4] ionic liquid as a solvent in one pot and gave products in good to excellent yields. Furthermore, the ionic liquid could be reused up to the 5(th) time without a considerable decrease in the reaction yield. Thirteen thiazoles were obtained in high yields (78-89%) under mild conditions (ambient temperature and relatively short reaction time) and their structures were confirmed by NMR data.

引用

页码：689 / 695

页数：7

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