The relationship between aquaporins and skin diseases

被引：4
|
作者：
Liu, Jiahao [1 ]
Jin, Yingji [2 ]
Wei, Qinqin [1 ]
Hu, Yewei [1 ]
Liu, Liu [1 ]
Feng, Yiran [3 ]
Jin, Yuji [4 ]
Jiang, Yong [1 ]
机构：
[1] Jilin Med Univ, Dept Lab Med, Jilin 132013, Jilin, Peoples R China
[2] Yanbian Univ Hosp, Dept Dermatol, Yanji 133000, Jilin, Peoples R China
[3] Jilin Med Univ, Dept publ Hlth, Jilin 132013, Jilin, Peoples R China
[4] Jilin Med Univ, Dept Basic Med, Jilin 132013, Jilin, Peoples R China
来源：
EUROPEAN JOURNAL OF DERMATOLOGY | 2023年 / 33卷 / 04期
关键词：
aquaporin; physiological function; dermatosis; mechanism; WATER CHANNEL; BARRIER FUNCTION; CELL MIGRATION; SWEAT GLAND; EXPRESSION; GLYCEROL; IMMUNOLOCALIZATION; PROLIFERATION; KERATINOCYTES; HYDRATION;
D O I：
10.1684/ejd.2023.4526
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Aquaporins (AQPs) are a family of transmembrane channel proteins that can rapidly transport water molecules. The main subtype expressed in the epidermis and dermis is AQP3. Studies have confirmed that AQPs exert certain physiological functions in the skin, such as the maintenance of normal shape, the regulation of body temperature, moisturization and hydration, anti-aging, damage repair and antigen presentation. The abnormal expression of AQPs in skin cells can lead to a variety of skin diseases. This review summarizes the relevance of AQPs in dermatophysiological and pathophysiological processes, highlighting their potential as new drug targets for the treatment of skin diseases.
引用
收藏
页码：350 / 359
页数：10
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