Improving Polygenic Risk Scores for Coronary Artery Disease What Helps and by How Much?

被引：0
|
作者：
Ajufo, Ezimamaka C. [1 ,2 ]
Aragam, Krishna G. [2 ,3 ,4 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA
[2] MIT & Harvard, Broad Inst, Cambridge, MA USA
[3] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA USA
[4] Massachusetts Gen Hosp, 185 Cambridge St,Simches Res Bldg 3-128, Boston, MA 02114 USA
来源：
JACC-BASIC TO TRANSLATIONAL SCIENCE | 2023年 / 8卷 / 12期
关键词：
biomarkers; coronary heart disease; FinnGen; genome-wide association studies; polygenic risk scores; PREDICTION;
D O I：
10.1016/j.jacbts.2023.10.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1580 / 1582
页数：3
相关论文
共 50 条
  • [21] Polygenic Hyperlipidemias and Coronary Artery Disease Risk
    Ripatti, Pietari
    Ramo, Joel T.
    Mars, Nina J.
    Fu, Yu
    Lin, Jake
    Soderlund, Sanni
    Benner, Christian
    Surakka, Ida
    Kiiskinen, Tuomo
    Havulinna, Aki S.
    Palta, Priit
    Freimer, Nelson B.
    Widen, Elisabeth
    Salomaa, Veikko
    Tukiainen, Taru
    Pirinen, Matti
    Palotie, Aarno
    Taskinen, Marja-Riitta
    Ripatti, Samuli
    CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2020, 13 (02): : E002725
  • [22] POLYGENIC HYPERLIPIDEMIA AND CORONARY ARTERY DISEASE RISK
    Ripatti, Pietari
    Ramo, Joel
    Soderlund, Sanni
    Surakka, Ida
    Matikainen, Niina
    Salomaa, Veikko
    Freimer, Nelson
    Palotie, Aarno
    Taskinen, Marja-Riitta
    Ripatti, Samuli
    ATHEROSCLEROSIS, 2017, 263 : E4 - E4
  • [23] Polygenic hyperlipidemias and coronary artery disease risk
    Ripatti, P.
    Ramo, J. T.
    Soderlund, S.
    Surakka, I.
    Havulinna, A. S.
    Freimer, N. B.
    Salomaa, V.
    Palotie, A.
    Taskinen, M.
    Ripatti, S.
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 142 - 142
  • [24] How group structure impacts the numbers at risk for coronary artery disease: polygenic risk scores and nongenetic risk factors in the UK Biobank cohort
    Zhao, Jinbo
    O'Hagan, Adrian
    Salter-Townshend, Michael
    GENETICS, 2024, 227 (03)
  • [25] POLYGENIC HYPERLIPIDEMIAS AND CORONARY ARTERY DISEASE RISK
    Ripatti, Pietari
    Soderlund, Sanni
    Ramo, Joel T.
    Surakka, Ida
    Havulinna, Aki S.
    Widen, Elisabeth
    Palta, Priit
    Freimer, Nelson B.
    Salomaa, Veikko
    Pirinen, Matti
    Palotie, Aarno
    Taskinen, Marja-Riitta
    Ripatti, Samuli
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2019, 73 (09) : 1690 - 1690
  • [26] Coronary Artery Disease Polygenic Risk Scores with Equivalent Performance Produce Discordant Estimates of Individual Risk
    Abramowitz, Sarah
    Boulier, Kristin
    Keat, Karl
    Cardone, Katie
    Shivakumar, Manu
    Depaolo, John
    Judy, Renae
    Kim, Dokyoon
    Ritchie, Marylyn
    Voight, Benjamin
    Pasaniuc, Bogdan
    Levin, Michael
    Damrauer, Scott
    CIRCULATION, 2024, 150
  • [27] Polygenic risk scores outperform machine learning methods in predicting coronary artery disease status
    Gola, Damian
    Erdmann, Jeannette
    Mueller-Myhsok, Bertram
    Schunkert, Heribert
    Koenig, Inke R.
    GENETIC EPIDEMIOLOGY, 2020, 44 (02) : 125 - 138
  • [28] Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French Canadians
    Wunnemann, Florian
    Lo, Ken Sin
    Langford-Avelar, Alexandra
    Busseuil, David
    Dube, Marie-Pierre
    Tardif, Jean-Claude
    Lettre, Guillaume
    CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2019, 12 (06): : e002481
  • [29] Polygenic Risk Scores in Predicting Coronary Artery Disease in Symptomatic Patients. A Validation Study
    Kujala, Iida
    Vangipurapu, Jagadish
    Maaniitty, Teemu
    Saraste, Antti
    Kere, Juha
    Knuuti, Juhani
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, 2024, 31 (07) : 1058 - 1071
  • [30] Comparison of Polygenic Risk Scores for Coronary Artery Disease in an Italian prospective cohort: the EPICOR study
    De Gregorio, Alessandro
    Debernardi, Carla
    Casalone, Elisabetta
    Cugliari, Giovanni
    Allione, Alessandra
    Iacoviello, Licia
    Tumino, Rosario
    Krogh, Vittorio
    Vineis, Paolo
    Panico, Salvatore
    Sacerdote, Carlotta
    Matullo, Giuseppe
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2023, 31 : 611 - 612
12345