Evaluation of 2,3-dihydroimidazo[2,1-b]oxazole and imidazo[2,1-b]oxazole derivatives as chemotherapeutic agents

被引：1

作者：

Shahin, Afnan, I ^{[1
]}

Zaraei, Seyed-Omar ^{[1
]}

Alzuraiqi, Shahed ^{[2
]}

Abdulateef, Zahaa ^{[2
]}

Abbas, Noora E. ^{[2
]}

Al-Tel, Taleb H. ^{[1
,2
]}

El-Gamal, Mohammed, I ^{[1
,2
,3
]}

机构：

[1] Univ Sharjah, Res Inst Med & Hlth Sci, Sharjah 27272, U Arab Emirates

[2] Univ Sharjah, Coll Pharm, Dept Med Chem, Sharjah 27272, U Arab Emirates

[3] Mansoura Univ, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt

来源：

FUTURE MEDICINAL CHEMISTRY | 2023年 / 15卷 / 20期

关键词：

2,3-dihydroimidazo[2,1-b]oxazole; anticancer; antimicrobial; delamanid; imidazo[2,1-b]oxazole; tuberculosis; ANTITUBERCULOSIS DRUG; DELAMANID; TOXICITY; INHIBIT; AGONIST;

D O I：

10.4155/fmc-2023-0147

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Imidazo[2,1-b]oxazole and 2,3-dihydroimidazo[2,1-b]oxazole ring systems are commonly employed in therapeutically active molecules. In this article, the authors review the utilization of these core scaffolds as chemotherapeutic agents from 2018 to 2022. These scaffolds possess many important biological activities including antimicrobial and anticancer, among others. This review covers their biological activities and structure-activity relationships. One of the most important drugs in this class of compounds is the antitubercular agent delamanid. In this paper, the compounds structure-activity relationship and preclinical and clinical trial data are thoroughly presented. [GRAPHICS] .

引用

页码：1885 / 1901

页数：17

共 50 条

[21] Design, synthesis, and anticancer activity of imidazo[2,1-b]oxazole-based RAF kinase inhibitors
Abdel-Maksoud, Mohammed S.
Ammar, Usama M.
El-Gamal, Mohammed I.
El-Din, Mahmoud M. Gamal
Mersal, Karim I.
Ali, Eslam M. H.
Yoo, Kyung Ho
Lee, Kyung-Tae
Oh, Chang-Hyun
BIOORGANIC CHEMISTRY, 2019, 93
[22] IMIDAZO[2,1-B]BENZOTHIAZOLES .2. NEW IMMUNOSUPPRESSIVE AGENTS
MASE, T
ARIMA, H
TOMIOKA, K
YAMADA, T
MURASE, K
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (03) : 386 - 394
[23] DERIVATIVES OF IMIDAZO (2,1-B) THIAZOLE .2. SYNTHESIS OF IMIDAZO (2,1-B) THIAZOLES WITH CARBONYL SIDE-CHAINS FROM 2-AMINOTHIAZOLE
ROBERT, JF
XICLUNA, A
PANOUSE, JJ
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1975, 10 (01) : 59 - 64
[24] 5,6 DIHYDRO-IMIDAZO[2,1-B]THIAZOLES, 2,3DIHYDRO-IMIDAZO[2,1-B]BENZOTHI AZOLES, ANALOGS OF LEVAMISOLE
AMAROUCH, H
LOISEAU, PR
BONNAFOUS, M
CAUJOLLE, R
PAYARD, M
FARMACO-EDIZIONE SCIENTIFICA, 1988, 43 (05): : 421 - 437
[25] ELECTROCHEMICAL INVESTIGATIONS OF ANTI-INFLAMMATORY AGENTS 5,6-SUBSTITUTED-2,3-DIHYDROIMIDAZO[2,1-B]THIAZOLES
CHENG, HY
DAVIS, LL
BENDER, PE
GLEASON, J
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 1989, 136 (12) : 3679 - 3683
[26] Synthesis and biological evaluation of novel imidazo[2,1-b]oxazole derivatives as V600E BRAF inhibitors for treatment of melanoma
Abdel-Maksoud, Mohammed
El-Gamal, Mohammed
Ammar, Usama
Ali, Eslam
Mersal, Karim
Choi, Hong
Oh, Chang
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
[27] Design, synthesis and biological evaluation of imidazo[2,1-b]thiazole and benzo[d]imidazo[2,1-b]thiazole derivatives as Mycobacterium tuberculosis pantothenate synthetase inhibitors
Samala, Ganesh
Devi, Parthiban Brindha
Saxena, Shalini
Meda, Nikhila
Yogeeswari, Perumal
Sriram, Dharmarajan
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 24 (06) : 1298 - 1307
[28] Electrophilic substitution of imidazo[2,1-b]oxazoles
Mekonnen, B.
Crank, G.
Tetrahedron, 53 (20):
[29] Combinatorial synthesis of imidazo[2,1-b]thiazole acyl derivatives
Bunev, Alexander
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
[30] ELECTROPHILIC SUBSTITUTION OF IMIDAZO[2,1-B]THIAZOLES
ODALY, MA
HOPKINSON, CP
MEAKINS, GD
RAYBOULD, AJ
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1991, (04): : 855 - 860

← 1 2 3 4 5 →