Viroid Replication, Movement, and the Host Factors Involved

被引:4
|
作者
Zhang, Yuhong [1 ]
Nie, Yuxin [1 ]
Wang, Luyou [1 ]
Wu, Jian [1 ]
机构
[1] Ningbo Univ, Inst Plant Virol, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Biotechnol Plant Protect MARA & Zhejiang P, Ningbo 315211, Peoples R China
基金
中国国家自然科学基金;
关键词
viroid; replication; trafficking; host factors; SPINDLE TUBER VIRUS; CELL-TO-CELL; RNA MOTIF; IN-VIVO; PROTEINS; TRAFFICKING; LIGASE; RESISTANT; COMPLEX; PAIRS;
D O I
10.3390/microorganisms12030565
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Viroids represent distinctive infectious agents composed solely of short, single-stranded, circular RNA molecules. In contrast to viruses, viroids do not encode for proteins and lack a protective coat protein. Despite their apparent simplicity, viroids have the capacity to induce diseases in plants. Currently, extensive research is being conducted on the replication cycle of viroids within both the Pospiviroidae and Avsunviroidae families, shedding light on the intricacies of the associated host factors. Utilizing the potato spindle tuber viroid as a model, investigations into the RNA structural motifs involved in viroid trafficking between different cell types have been thorough. Nevertheless, our understanding of the host factors responsible for the intra- and inter-cellular movement of viroids remains highly incomplete. This review consolidates our current knowledge of viroid replication and movement within both families, emphasizing the structural basis required and the identified host factors involved. Additionally, we explore potential host factors that may mediate the intra- and inter-cellular movement of viroids, addressing gaps in our understanding. Moreover, the potential application of viroids and the emergence of novel viroid-like cellular parasites are also discussed.
引用
收藏
页数:13
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