The potential of BRD4 inhibition in tumour mechanosignaling

被引:1
|
作者
Gargalionis, Antonios N. [1 ]
Papavassiliou, Kostas A. [2 ]
Papavassiliou, Athanasios G. [3 ]
机构
[1] Natl & Kapodistrian Univ Athens, Eginition Hosp, Med Sch, Dept Biopathol, Athens, Greece
[2] Natl & Kapodistrian Univ Athens, Univ Dept Resp Med 1, Sotiria Hosp, Med Sch, Athens, Greece
[3] Natl & Kapodistrian Univ Athens, Med Sch, Dept Biol Chem, 75 Mikras Asias St,Bldg 16, Athens 11527, Greece
关键词
BRD4; mechanosignaling; targeted therapy; TAZ; tumour inhibitor; YAP; YAP/TAZ;
D O I
10.1111/jcmm.18057
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
[No abstract available]
引用
收藏
页码:4215 / 4218
页数:4
相关论文
共 50 条
  • [41] Unlocking the therapeutic potential of selective CDK7 and BRD4 inhibition against multiple myeloma cell growth
    Yao, Yao
    Deng, Shuhui
    Ng, Jessica Fong
    Yuan, Mei
    Chakraborty, Chandraditya
    Weiler, Vera Joy
    Munshi, Nikhil
    Fulciniti, Mariateresa
    HAEMATOLOGICA, 2025, 110 (01) : 153 - 162
  • [42] Transcription Factor Brd4, a Potential Marker of Corneal Epithelial Stem Cells
    Li, Cheng
    Xue, Yuhua
    Li, Wei
    Liu, Zuguo
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (13)
  • [43] Design, synthesis and biological evaluation of coumarin derivatives as potential BRD4 inhibitors
    Cui, Qi-Hang
    Li, Wen-Bo
    Wang, Zhao-Yang
    Xu, Kai-Yan
    Wang, Shuai
    Shi, Jian-Tao
    Zhang, Li-Wen
    Chen, Shi-Wu
    BIOORGANIC CHEMISTRY, 2022, 128
  • [44] BRD4 degradation by PROTACs represents a more effective therapeutic strategy than BRD4 inhibitors in ovarian cancer
    Raina, Kanak
    Lu, Jing
    Qian, Yimin
    Altieri, Martha
    Dong, Hanging
    Wang, Jing
    Chen, Xin
    Crew, Andrew
    Coleman, Kevin
    Crews, Craig
    Winkler, James
    CANCER RESEARCH, 2016, 76
  • [45] Inhibition of BRD4 suppresses tumor growth and enhances iodine uptake in thyroid cancer
    Gao, Xuemei
    Wu, Xinchao
    Zhang, Xiao
    Hua, Wenjuan
    Zhang, Yajing
    Maimaiti, Yusufu
    Gao, Zairong
    Zhang, Yongxue
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016, 469 (03) : 679 - 685
  • [46] Inhibition of the Epigenetic Reader BRD4 Reduces SIRPα-Mediated Phagocytosis and Melanoma Invasion
    Scheeren, Ferenc A.
    van Doorn, Remco
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2021, 141 (02) : 252 - 254
  • [47] Inhibition of BRD4 suppresses the malignancy of breast cancer cells via regulation of Snail
    Lu, Linlin
    Chen, Zhuojia
    Lin, Xinyao
    Tian, Lin
    Su, Qiao
    An, Panpan
    Li, Wuguo
    Wu, Yingmin
    Du, Jun
    Shan, Hong
    Chiang, Cheng-Ming
    Wang, Hongsheng
    CELL DEATH AND DIFFERENTIATION, 2020, 27 (01): : 255 - 268
  • [48] BRD4 inhibitors block telomere elongation
    Wang, Steven
    Pike, Alexandra M.
    Lee, Stella S.
    Strong, Margaret A.
    Connelly, Carla J.
    Greider, Carol W.
    NUCLEIC ACIDS RESEARCH, 2017, 45 (14) : 8403 - 8410
  • [49] BRD4 Inhibition Enhances Azacitidine Efficacy in Acute Myeloid Leukemia and Myelodysplastic Syndromes
    Pericole, Fernando Vieira
    Lazarini, Mariana
    de Paiva, Luciana Bueno
    Santos Duarte, Adriana da Silva
    Vieira Ferro, Karla Priscila
    Niemann, Fernanda Soares
    Roversi, Fernanda Marconi
    Olalla Saad, Sara Teresinha
    FRONTIERS IN ONCOLOGY, 2019, 9
  • [50] Review on: BRD4 inhibitors for anticancer research
    Singh, Vindhya Vikram
    Alauddin, Shafqat
    HUMAN GENE, 2023, 37