Generation of an induced pluripotent stem cell line from an aortic dissection patient carrying MCTP2/c.2635T > G mutation

被引：0
|
作者：
Feng, Weiqi [1 ,2 ]
Li, Chenxi [3 ]
Li, Ying [2 ]
Yang, Jue [2 ]
Fan, Ruixin [1 ,2 ,4 ]
机构：
[1] South China Univ Technol, Sch Med, Guangzhou 510006, Peoples R China
[2] Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci, Dept Cardiovasc Surg, Guangzhou, Peoples R China
[3] Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci, Dept Cardiac Surg,Intens Care Unit, Guangzhou, Peoples R China
[4] Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangdong Acad Med Sci, Dept Cardiovasc Surg, Guangzhou 510000, Guangdong, Peoples R China
来源：
STEM CELL RESEARCH | 2023年 / 68卷
关键词：
D O I：
10.1016/j.scr.2023.103058
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Aortic dissection (AD) is a lethal cardiovascular disease that is related to a genetic mutation. This study showed the generation of induced pluripotent stem cell (iPSC) line (iPSC-ZPR-4-P10) from AD patients' peripheral blood mononuclear cells that carried a c.2635T > G mutation in MCTP2. The iPSC line demonstrated normal karyotype and expression of pluripotency markers, which could be an efficient tool to better investigate the mechanism of aortic dissection.
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