Three new proaporphine alkaloids from Cissampelos capensis L.f. and their cytotoxic evaluation

被引：4

作者：

Latolla, Nehemiah ^{[1
]}

Hlangothi, Buyiswa ^{[1
]}

机构：

[1] Nelson Mandela Univ, Dept Chem, Gqeberha, South Africa

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 18期

关键词：

Cissampelos capensis; proaporphine alkaloids; cytotoxicity;

D O I：

10.1080/14786419.2022.2146687

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Three new proaporphine alkaloids, cissamaline (4), cissamanine (5), and cissamdine (6), along with two known compounds (2 and 3) were isolated from total tertiary alakloidal extracts of the leaves and stems of Cissampelos capensis. The new alkaloids were elucidated through comprehensive spectroscopic analysis, including 1 D, 2 D NMR and High-resolution LCMS. The in vitro MTT cytotoxicity was evaluated on Caco-2 cell lines, where all the isolated compounds exhibited cytotoxic effects at concentrations above 250 mu M.

引用

页码：3065 / 3073

页数：9

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