Recent advances in ocular graft-versus-host disease

被引：13

作者：

Cheng, Xianjing ^{[1
,2
]}

Huang, Ruihao ^{[1
]}

Huang, Shiqin ^{[1
]}

Fan, Wei ^{[3
]}

Yuan, Rongdi ^{[3
]}

Wang, Xiaoqi ^{[1
]}

Zhang, Xi ^{[1
,2
,4
]}

机构：

[1] Army Med Univ, Xinqiao Hosp, State Key Lab Trauma Burns & Combined Injury, Med Ctr Hematol, Chongqing, Peoples R China

[2] Chongqing Univ, Sch Med, Chongqing, Peoples R China

[3] Army Med Univ, Xinqiao Hosp, Dept Ophthalmol, Chongqing, Peoples R China

[4] Jinfeng Lab, Chongqing, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

ocular graft-versus-host-disease; clinical characteristics; the pathogenic mechanism; novel therapeutic targets; tear biomarkers; STEM-CELL TRANSPLANTATION; SERUM EYE DROPS; CONSENSUS DEVELOPMENT PROJECT; MEIBOMIAN GLAND DYSFUNCTION; MESENCHYMAL STROMAL CELLS; DRY EYE; LACRIMAL GLAND; CLINICAL-TRIALS; LONGITUDINAL ANALYSIS; RANDOMIZED-TRIAL;

D O I：

10.3389/fimmu.2023.1092108

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other symptoms severely affect affected individuals' quality of life. However, the diagnosis of and therapy for ocular GVHD involve a multidisciplinary approach and remain challenging for both hematologists and ophthalmologists, as there are no unified international criteria. Through an exploration of the complex pathogenesis of ocular GVHD, this review comprehensively summarizes the pathogenic mechanism, related tear biomarkers, and clinical characteristics of this disease. Novel therapies based on the mechanisms are also discussed to provide insights into the ocular GVHD treatment.

引用

页数：15

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