EAACI guidelines on the diagnosis of IgE-mediated food allergy

被引：88

作者：

Santos, Alexandra F. ^{[1
,2
,3
,83
]}

Riggioni, Carmen ^{[4
]}

Agache, Ioana ^{[5
]}

Akdis, Cezmi A. ^{[6
]}

Akdis, Mubeccel ^{[6
]}

Alvarez-Perea, Alberto ^{[7
,8
]}

Alvaro-Lozano, Montserrat ^{[9
,10
]}

Ballmer-Weber, Barbara ^{[11
,12
]}

Barni, Simona ^{[13
]}

Beyer, Kirsten ^{[14
]}

Bindslev-Jensen, Carsten ^{[15
,16
]}

Brough, Helen A. ^{[1
,3
]}

Buyuktiryaki, Betul ^{[17
]}

Chu, Derek ^{[18
]}

Del Giacco, Stefano ^{[19
]}

Dunn-Galvin, Audrey ^{[20
,21
]}

Eberlein, Bernadette ^{[22
]}

Ebisawa, Motohiro ^{[23
]}

Eigenmann, Philippe ^{[24
]}

Eiwegger, Thomas ^{[25
,26
,27
,28
]}

Feeney, Mary ^{[1
]}

Fernandez-Rivas, Montserrat ^{[29
,30
]}

Fisher, Helen R. ^{[1
]}

Fleischer, David M. ^{[31
]}

Giovannini, Mattia ^{[13
,32
]}

Gray, Claudia ^{[33
,34
]}

Hoffmann-Sommergruber, Karin ^{[35
]}

Halken, Susanne ^{[36
]}

Hourihane, Jonathan O'B. ^{[37
,38
]}

Jones, Christina J. ^{[39
]}

Jutel, Marek ^{[40
]}

Knol, Edward ^{[41
]}

Konstantinou, George N. ^{[42
]}

Lack, Gideon ^{[1
,2
,3
]}

Lau, Susanne ^{[14
]}

Marques Mejias, Andreina ^{[1
,3
]}

Marchisotto, Mary Jane ^{[43
]}

Meyer, Rosan ^{[44
,45
,46
]}

Mortz, Charlotte G. ^{[15
,16
]}

Moya, Beatriz ^{[47
,48
]}

Muraro, Antonella ^{[49
]}

Nilsson, Caroline ^{[50
,51
]}

Lopes de Oliveira, Lucila Camargo ^{[52
]}

O'Mahony, Liam ^{[53
]}

Papadopoulos, Nikolaos G. ^{[54
,55
]}

Perrett, Kirsten ^{[56
,57
,58
]}

Peters, Rachel L. ^{[56
,57
,58
]}

Podesta, Marcia ^{[59
]}

Poulsen, Lars K. ^{[60
]}

Roberts, Graham ^{[61
,62
,63
]}

机构：

[1] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth Pediat Allergy, London, England

[2] Kings Coll London, Sch Immunol & Microbial Sci, Peter Gorer Dept Immunobiol, London, England

[3] Guys & St Thomas Hosp, Evelina London Childrens Hosp, Childrens Allergy Serv, London, England

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Allergy & Clin Immunol, Dept Paediat, Singapore, Singapore

[5] Transylvania Univ, Fac Med, Brasov, Romania

[6] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[7] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[8] Gregorio Maranon Hlth Res Inst, Madrid, Spain

[9] Hosp St Joan de Deu, Pediat Allergy & Clin Immunol Dept, Barcelona, Spain

[10] Univ Barcelona, Inst Recerca St Joan de Deu, Barcelona, Spain

[11] Kantonsspital St Gallen, Clin Dermatol & Allergol, St Gallen, Switzerland

[12] Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland

[13] Meyer Childrens Hosp IRCCS, Allergy Unit, Florence, Italy

[14] Charite Univ Med Berlin, Dept Pediat Resp Med Immunol & Crit Care Med, Berlin, Germany

[15] Univ Southern Denmark, Odense Univ Hosp, Dept Dermatol, Odense Res Ctr Anaphylaxis ORCA, Odense, Denmark

[16] Univ Southern Denmark, Odense Univ Hosp, Allergy Ctr, Odense Res Ctr Anaphylaxis ORCA, Odense, Denmark

[17] Koc Univ, Sch Med, Dept Pediat, Div Pediat Allergy, Istanbul, Turkiye

[18] McMaster Univ, Hamilton, ON, Canada

[19] Univ Cagliari, Univ Hosp Duilio Casula, Dept Med Sci & Publ Hlth, I-09042 Cagliari, Italy

[20] Univ Coll Cork, INFANT Ctr, Paediat & Child Hlth, HRB CRF, Cork, Ireland

[21] Royal Coll Surgeons Ireland, Paediat & Child Hlth, Childrens Hlth Ireland, Dublin, Ireland

[22] Tech Univ Munich, TUM Sch Med & Hlth, Dept Dermatol & Allergy Biederstein, Munich, Germany

[23] Natl Hosp Org Sagamihara Natl Hosp, Clin Res Ctr Allergy & Rheumatol, Sagamihara, Kanagawa, Japan

[24] Univ Hosp Geneva, Dept Pediat Gynecol & Obstet, Geneva, Switzerland

[25] Hosp Sick Children, Res Inst, Translat Med Program, Toronto, ON, Canada

[26] Univ Toronto, Temerty Fac Med, Dept Immunol, Toronto, ON, Canada

[27] Karl Landsteiner Univ Hlth Sci, Krems An Der Donau, Austria

[28] Univ Hosp St Polten, Dept Pediat & Adolescent Med, St Polten, Austria

[29] Hosp Clin San Carlos, Allergy Dept, Madrid, Spain

[30] Univ Complutense, Fac Med, IdISSC, ARADyAL, Madrid, Spain

[31] Univ Colorado, Sch Med, Childrens Hosp Colorado, Aurora, CO USA

[32] Univ Florence, Dept Hlth Sci, Florence, Italy

[33] Red Cross Childrens Hosp & Kidsallergy Ctr, Cape Town, South Africa

[34] Univ Cape Town, Dept Paediat, Cape Town, South Africa

[35] Med Univ Vienna, Inst Pathophysiol & Allergy Res, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria

[36] Odense Univ Hosp, Hans Christian Andersen Childrens Hosp, Odense, Denmark

[37] Royal Coll Surgeons Ireland, Dublin, Ireland

[38] Childrens Hlth Ireland, Dublin, Ireland

[39] Univ Surrey, Sch Psychol, Fac Hlth & Med Sci, Guildford, Surrey, England

[40] Wroclaw Med Univ, ALL MED Med Res Inst, Dept Clin Immunol, Wroclaw, Poland

[41] Univ Med Ctr Utrecht, Ctr Translat Immunol, Dept Dermatol Allergol, Utrecht, Netherlands

[42] 424 Gen Mil Training Hosp, Dept Allergy & Clin Immunol, Thessaloniki, Greece

[43] MJM Advisory, New York, NY USA

[44] Imperial Coll, Dept Med, London, England

[45] Winchester Univ, Dept Nutr & Dietet, Winchester, England

[46] Katholieke Univ Leuven, Dept Med, Leuven, Belgium

[47] Hosp Univ 12 Octubre, Dept Allergy, Madrid, Spain

[48] Hosp 12 Octubre Imas12, Inst Invest Sanitaria, Madrid, Spain

[49] Padua Univ Hosp, Food Allergy Referral Ctr, Padua, Italy

[50] Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden

来源：

ALLERGY | 2023年 / 78卷 / 12期

关键词：

basophil activation test; diagnosis; food allergy; oral food challenges; skin prick test; specific IgE; DOUBLE-BLIND; ADVERSE-REACTIONS; EUROPEAN ACADEMY; CHALLENGE TESTS; PEANUT ALLERGEN; POSITION PAPER; SENSITIZATION; CHILDREN; ANAPHYLAXIS; PREVALENCE;

D O I：

10.1111/all.15902

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This European Academy of Allergy and Clinical Immunology guideline provides recommendations for diagnosing IgE-mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Food allergy diagnosis starts with an allergy-focused clinical history followed by tests to determine IgE sensitization, such as serum allergen-specific IgE (sIgE) and skin prick test (SPT), and the basophil activation test (BAT), if available. Evidence for IgE sensitization should be sought for any suspected foods. The diagnosis of allergy to some foods, such as peanut and cashew nut, is well supported by SPT and serum sIgE, whereas there are less data and the performance of these tests is poorer for other foods, such as wheat and soya. The measurement of sIgE to allergen components such as Ara h 2 from peanut, Cor a 14 from hazelnut and Ana o 3 from cashew can be useful to further support the diagnosis, especially in pollen-sensitized individuals. BAT to peanut and sesame can be used additionally. The reference standard for food allergy diagnosis is the oral food challenge (OFC). OFC should be performed in equivocal cases. For practical reasons, open challenges are suitable in most cases. Reassessment of food allergic children with allergy tests and/or OFCs periodically over time will enable reintroduction of food into the diet in the case of spontaneous acquisition of oral tolerance.

引用

页码：3057 / 3076

页数：20

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