20S-Protopanaxatriol improves cognitive function of Alzheimer's disease by promoting endogenous neurogenesis

被引：1
|
作者：
Zhang, Qiang [1 ]
Yang, Xuehan [1 ]
Liu, Jingyue [1 ]
Song, Jiayi [1 ]
Zhang, Siwei [1 ]
Chen, Li [1 ,2 ]
Zhang, Ming [1 ]
机构：
[1] Jilin Univ, Coll Basic Med Sci, Dept Pharmacol, Changchun, Jilin, Peoples R China
[2] Jilin Univ, Sch Nursing, Changchun, Peoples R China
来源：
FOOD & FUNCTION | 2023年 / 14卷 / 09期
关键词：
STEM-CELLS; MECHANISMS; GINSENG;
D O I：
10.1039/d2fo03191d
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neurogenesis in Alzheimer's disease (AD) is impaired, and thus promoting neurogenesis is a promising strategy for treating AD-related cognition impairment. Here, we found that 20S-protopanaxatriol (PPT) can alleviate cognitive deficits in an AlCl3-induced AD zebrafish model in Y and T maze tests and increase the HUC expression of the telencephalon. PPT promotes neural stem cell (NSC) line differentiation into neurons under AD condition. PPT significantly alleviated the apoptosis and cell cycle arrest of NSCs induced by amyloid-beta. Next, we investigated the molecular mechanism of PPT in treating AD by network pharmacology and molecular docking. PPT could target PIK3CA and PI3K/AKT signaling pathways. PPT significantly reversed the reduced expression level of PIK3CA (PI3K p110), p-PI3Kp85 and p-AKT of NSCs under AD condition. These results suggested that PPT alleviated the cognitive dysfunction of AD and promoted NSC proliferation and neurogenesis through the PI3K/AKT pathway. Therefore, PPT might be a potential candidate to treat AD-related cognitive decline via enhancing endogenous neurogenesis.
引用
收藏
页码：4191 / 4203
页数：13
相关论文
共 50 条
  • [41] CAPROSPINOL REDUCES AMYLOID DEPOSITS AND IMPROVES COGNITIVE FUNCTION IN A RAT MODEL OF ALZHEIMER'S DISEASE
    Lecanu, L.
    Rammouz, G.
    McCourty, A.
    Sidahmed, E. K.
    Greeson, J.
    Papadopoulos, V.
    NEUROSCIENCE, 2010, 165 (02) : 427 - 435
  • [42] Kihito, a Traditional Japanese Kampo Medicine, Improves Cognitive Function in Alzheimer's Disease Patients
    Watari, Hidetoshi
    Shimada, Yutaka
    Matsui, Mie
    Tohda, Chihiro
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2019, 2019
  • [43] CPAP improves cognitive function in Alzheimer's disease patients with sleep apnea: Preliminary results
    Ancoli-Israel, S
    Palmer, B
    Loredo, J
    Corely-Bloom, J
    Marler, M
    Greenfield, D
    SLEEP, 2005, 28 : A110 - A111
  • [44] Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer's Disease
    Biscaro, Barbara
    Lindvall, Olle
    Tesco, Giuseppina
    Ekdahl, Christine T.
    Nitsch, Roger M.
    NEURODEGENERATIVE DISEASES, 2012, 9 (04) : 187 - 198
  • [45] Plasmalogen Improves Memory Function by Regulating Neurogenesis in a Mouse Model of Alzheimer's Diseases
    Li, Rongzi
    Xiong, Wei
    Li, Boying
    Li, Yixuan
    Fang, Bing
    Wang, Xifan
    Ren, Fazheng
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (15)
  • [46] DRUGS TO IMPROVE COGNITIVE FUNCTION IN ALZHEIMER'S DISEASE
    Giacobini, E.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2009, 105 : 8 - 8
  • [47] Depression, cognitive impairment and function in Alzheimer's disease
    Espiritu, DAV
    Rashid, H
    Mast, BT
    Fitzgerald, J
    Steinberg, J
    Lichtenberg, PA
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2001, 16 (11) : 1098 - 1103
  • [48] Correlation of cognitive and masticatory function in Alzheimer’s disease
    Camila Heitor Campos
    Giselle Rodrigues Ribeiro
    José Luiz Riani Costa
    Renata Cunha Matheus Rodrigues Garcia
    Clinical Oral Investigations, 2017, 21 : 573 - 578
  • [49] Correlation of cognitive and masticatory function in Alzheimer's disease
    Campos, Camila Heitor
    Ribeiro, Giselle Rodrigues
    Riani Costa, Jose Luiz
    Matheus Rodrigues Garcia, Renata Cunha
    CLINICAL ORAL INVESTIGATIONS, 2017, 21 (02) : 573 - 578
  • [50] Acute Exercise and Cognitive Function in Alzheimer's Disease
    Ben Ayed, Ines
    Castor-Guyonvarch, Naomie
    Amimour, Souad
    Naija, Salma
    Aouichaoui, Chirine
    Ben Omor, Sana
    Tabka, Zouhair
    El Massioui, Farid
    JOURNAL OF ALZHEIMERS DISEASE, 2021, 82 (02) : 749 - 760
12345