Artificial intelligence aids in development of nanomedicines for cancer management

被引:116
|
作者
Tan, Ping [1 ]
Chen, Xiaoting [1 ]
Zhang, Hu [2 ]
Wei, Qiang [1 ]
Luo, Kui [1 ]
机构
[1] Sichuan Univ, West China Hosp, Inst Urol, Huaxi MR Res Ctr HMRRC, Chengdu 610041, Peoples R China
[2] Keck Grad Inst, Amgen Bioproc Ctr, Claremont, CA 91711 USA
基金
中国国家自然科学基金;
关键词
Artificial intelligence; Nanomedicine; Cancer nanomedicine; Nanotechnology; Precision medicine; SINGLE-MOLECULE ANALYSIS; HIGH-THROUGHPUT; IN-VIVO; COMPUTER-SIMULATION; COMBINATION THERAPY; PROTEIN CORONA; HEALTH-CARE; DRUG; NANOPARTICLES; DELIVERY;
D O I
10.1016/j.semcancer.2023.01.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Over the last decade, the nanomedicine has experienced unprecedented development in diagnosis and management of diseases. A number of nanomedicines have been approved in clinical use, which has demonstrated the potential value of clinical transition of nanotechnology-modified medicines from bench to bedside. The application of artificial intelligence (AI) in development of nanotechnology-based products could transform the healthcare sector by realizing acquisition and analysis of large datasets, and tailoring precision nanomedicines for cancer management. AI-enabled nanotechnology could improve the accuracy of molecular profiling and early diagnosis of patients, and optimize the design pipeline of nanomedicines by tuning the properties of nanomedicines, achieving effective drug synergy, and decreasing the nanotoxicity, thereby, enhancing the targetability, personalized dosing and treatment potency of nanomedicines. Herein, the advances in AI-enabled nanomedicines in cancer management are elaborated and their application in diagnosis, monitoring and therapy as well in precision medicine development is discussed.
引用
收藏
页码:61 / 75
页数:15
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