Endocrine side effects of immune checkpoint inhibitors

被引：17
|
作者：
Cardona, Zulma [1 ]
Sosman, Jeffrey A. [2 ]
Chandra, Sunandana [2 ]
Huang, Wenyu [1 ]
机构：
[1] Northwestern Univ, Div Endocrinol Metab & Mol Med, Feinberg Sch Med, Chicago, IL 60611 USA
[2] Northwestern Univ, Div Hematol & Oncol, Feinberg Sch Med, Chicago, IL USA
来源：
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
关键词：
immune checkpoint inhibitor (ICI); endocrine side effects; hypophysitis; thyroiditis; type1; diabetes; adrenalitis; adrenal insufficiency; central diabetes insipidus; IPILIMUMAB-INDUCED HYPOPHYSITIS; CELL LUNG-CANCER; QUALITY-OF-LIFE; ADVERSE EVENTS; RETROSPECTIVE ANALYSIS; ADRENAL INSUFFICIENCY; THYROID ANTIBODIES; PD-1; EXPRESSION; NIVOLUMAB; MANAGEMENT;
D O I：
10.3389/fendo.2023.1157805
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Immune checkpoint inhibitors (ICIs) have increasingly been the mainstay of treatment for numerous malignancies. However, due to their association with autoimmunity, ICIs have resulted in a variety of side effects that involve multiple organs including the endocrine system. In this review article, we describe our current understanding of the autoimmune endocrinopathies as a result of the use of ICIs. We will review the epidemiology, pathophysiology, clinical presentation, diagnosis, and management of the most commonly encountered endocrinopathies, including thyroiditis, hypophysitis, Type 1 diabetes, adrenalitis, and central diabetes insipidus.
引用
收藏
页数：12
相关论文
共 50 条
  • [31] The Current Understanding of the Endocrine Effects From Immune Checkpoint Inhibitors and Recommendations for Management
    Girotra, Monica
    Hansen, Aaron
    Farooki, Azeez
    Byun, David J.
    Min, Le
    Creelan, Ben C.
    Callahan, Margaret K.
    Atkins, Michael B.
    Sharon, Elad
    Antonia, Scott J.
    West, Pamela
    Gravell, Amy E.
    JNCI CANCER SPECTRUM, 2018, 2 (03)
  • [32] Indications and side effects of checkpoint inhibitors
    Delecluse, S.
    Zschaebitz, S.
    Neuendorff, N. R.
    Zeier, M.
    NEPHROLOGE, 2020, 15 (02): : 87 - 94
  • [33] Checkpoint inhibitors neurological side effects
    Suay, Guillermo
    Bataller, Luis
    REVISTA DE NEUROLOGIA, 2019, 68 (07) : 301 - 311
  • [34] Neurological side effects of checkpoint inhibitors
    Knauss, S.
    Roque, L. Ginesta
    Huehnchen, P.
    Heinzerling, L.
    Boehmerle, W.
    Endres, M.
    NERVENARZT, 2019, 90 (02): : 138 - 147
  • [35] Ocular side effects of checkpoint inhibitors
    Alba-Linero, Carmen
    Alba, Emilio
    SURVEY OF OPHTHALMOLOGY, 2021, 66 (06) : 951 - 959
  • [36] Cardiac Side Effects during Therapy with Immune Checkpoint Inhibitors - A Case Report
    Mueller, F.
    Kellner, I.
    Herbst, R.
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2021, 19 : 75 - 75
  • [37] Endocrine, Sexual Function, and Infertility Side Effects of Immune Checkpoint Inhibitor Therapy for Genitourinary Cancers
    Akshay Sood
    Daniel Cole
    Firas Abdollah
    Ben Eilender
    Zade Roumayah
    Mustafa Deebajah
    Ali Dabaja
    Shaheen Alanee
    Current Urology Reports, 2018, 19
  • [38] Immune Checkpoint Inhibitors: Review and Management of Endocrine Adverse Events
    Gonzalez-Rodriguez, Elisa
    Rodriguez-Abreu, Delvys
    ONCOLOGIST, 2016, 21 (07): : 804 - 816
  • [39] Immune checkpoint inhibitors, endocrine adverse events, and outcomes of melanoma
    Karhapaa, Hanna
    Makela, Siru
    Lauren, Hanna
    Jaakkola, Marjut
    Schalin-Jantti, Camilla
    Hernberg, Micaela
    ENDOCRINE CONNECTIONS, 2022, 11 (02)
  • [40] Endocrine, Sexual Function, and Infertility Side Effects of Immune Checkpoint Inhibitor Therapy for Genitourinary Cancers
    Sood, Akshay
    Cole, Daniel
    Abdollah, Firas
    Eilender, Ben
    Roumayah, Zade
    Deebajah, Mustafa
    Dabaja, Ali
    Alanee, Shaheen
    CURRENT UROLOGY REPORTS, 2018, 19 (09)
12345