Bacterial Contamination of Open Fractures: Pathogens and Antibiotic Resistance Patterns in East China

被引:2
|
作者
Zhong, Wanrun [1 ]
Wang, Yanmao [1 ]
Wang, Hongshu [1 ]
Han, Pei [1 ]
Sun, Yi [1 ]
Chai, Yimin [1 ]
Lu, Shengdi [1 ]
Hu, Chengfang [1 ]
机构
[1] Shanghai Jiao Tong Univ, Dept Orthopaed, Shanghai Peoples Hosp 6, Sch Med, Shanghai 200235, Peoples R China
来源
JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 05期
基金
中国国家自然科学基金;
关键词
bacterial contamination; open fractures; pathogens; East China; PRACTICE MANAGEMENT GUIDELINES; TRAUMA;
D O I
10.3390/jpm13050735
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Bacterial contamination of soft tissue in open fractures leads to high infection rates. Pathogens and their resistance against therapeutic agents change with time and vary in different regions. The purpose of this study was to characterize the bacterial spectrum present in open fractures and analyze the bacterial resistance to antibiotic agents based on five trauma centers in East China. A retrospective multicenter cohort study was conducted in six major trauma centers in East China from January 2015 to December 2017. Patients who sustained open fractures of the lower extremities were included. The data collected included the mechanism of injury, the Gustilo-Anderson classification, the isolated pathogens and their resistance against therapeutic agents, as well as the prophylactic antibiotics administered. In total, 1348 patients were included in our study, all of whom received antibiotic prophylaxis (cefotiam or cefuroxime) during the first debridement at the emergency room. Wound cultures were taken in 1187 patients (85.8%); the results showed that the positive rate of open fracture was 54.8% (651/1187), and 59% of the bacterial detections occurred in grade III fractures. Most pathogens (72.7%) were sensitive to prophylactic antibiotics, according to the EAST guideline. Quinolones and cotrimoxazole showed the lowest rates of resistance. The updated EAST guidelines for antibiotic prophylaxis in open fracture (2011) have been proven to be adequate for a large portion of patients, and we would like to suggest additional Gram-negative coverage for patients with grade II open fractures based on the results obtained in this setting in East China.
引用
收藏
页数:9
相关论文
共 50 条
  • [41] Assessment of the Role of Wastewater Treatment Plant in Spread of Antibiotic Resistance and Bacterial Pathogens
    Yogesh S. Nimonkar
    Bhoomika Yadav
    Payal Talreja
    Ashutosh Sharma
    Shalaka Patil
    Sunita S. Saware
    Dilip R. Ranade
    Om Prakash
    Indian Journal of Microbiology, 2019, 59 : 261 - 265
  • [42] Assessment of the Role of Wastewater Treatment Plant in Spread of Antibiotic Resistance and Bacterial Pathogens
    Nimonkar, Yogesh S.
    Yadav, Bhoomika
    Talreja, Payal
    Sharma, Ashutosh
    Patil, Shalaka
    Saware, Sunita S.
    Ranade, Dilip R.
    Prakash, Om
    INDIAN JOURNAL OF MICROBIOLOGY, 2019, 59 (03) : 261 - 265
  • [43] Proteomic Approaches to Unravel Mechanisms of Antibiotic Resistance and Immune Evasion of Bacterial Pathogens
    Torres-Sangiao, Eva
    Giddey, Alexander Dyason
    Leal Rodriguez, Cristina
    Tang, Zhiheng
    Liu, Xiaoyun
    Soares, Nelson C.
    FRONTIERS IN MEDICINE, 2022, 9
  • [44] Antibiotic resistance among common bacterial enteric pathogens isolated from stool
    B. V. Navaneeth
    N. Suganthi
    M. R. Sandhya Belwadi
    The Indian Journal of Pediatrics, 2001, 68 (7) : 687 - 688
  • [45] CRISPR-Cas is associated with fewer antibiotic resistance genes in bacterial pathogens
    Pursey, Elizabeth
    Dimitriu, Tatiana
    Paganelli, Fernanda L.
    Westra, Edze R.
    van Houte, Stineke
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2022, 377 (1842)
  • [46] Microorganisms and antibiotic sensitivity/resistance patterns in spontaneous bacterial peritonitis
    Alhilly, Ahmed Abdul Hussain Gburi
    Alyouzbaki, Abdullah Zuhair
    RAWAL MEDICAL JOURNAL, 2023, 48 (03): : 622 - 629
  • [47] Proteomics in antibiotic resistance and tolerance research: Mapping the resistome and the tolerome of bacterial pathogens
    Sulaiman, Jordy Evan
    Lam, Henry
    PROTEOMICS, 2022, 22 (08)
  • [48] Bottlenecks in the transferability of antibiotic resistance from natural ecosystems to human bacterial pathogens
    Martinez, Jose L.
    FRONTIERS IN MICROBIOLOGY, 2012, 3
  • [49] The Emergence of Different Bacterial Pathogens in Hospital Wastewater Samples and their Antibiotic Resistance Pattern
    Asim Shahzad
    Abrar Hussain Mian
    Ihtesham Ul haq
    Muhammad Azam Khan
    Kashmala Matiullah
    Tauseef Ali
    Materials Circular Economy, 2021, 3 (1):
  • [50] Persistence of bacterial pathogens, antibiotic resistance genes, and enterococci in tidal creek tributaries
    Jones, Chance E.
    Maddox, Anthony
    Hurley, Dorset
    Barkovskii, Andrei L.
    ENVIRONMENTAL POLLUTION, 2018, 240 : 875 - 883