CDT1, a licensing factor that limits rereplication

被引：1
|
作者：
Rona, Gergely [1 ,2 ,3 ]
Pagano, Michele [1 ,2 ,3 ]
机构：
[1] Dept Biochem & Mol Pharmacol, New York, NY 10016 USA
[2] Laura & Isaac Perlmutter NYU Canc Ctr, New York, NY 10016 USA
[3] New York Univ, Howard Hughes Med Inst, Grossman Sch Med, New York, NY 10016 USA
来源：
MOLECULAR CELL | 2023年 / 83卷 / 01期
关键词：
DNA-REPLICATION; GEMININ;
D O I：
10.1016/j.molcel.2022.11.019
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cells must avoid licensing of neosynthesized DNA to prevent rereplication. In this issue of Molecular Cell, Ratnayeke et al. (2022)(1) reveal how the licensing factor CDT1, prior to its degradation, inhibits DNA elongation by suppressing CMG helicase progression at replication forks.
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页数：3
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