Life, the genome and everything

被引：0

作者：

Rosenberg, Susan M. ^{[1
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机构：

[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dan Duncan Comprehens Canc Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF BACTERIOLOGY | 2023年 / 205卷 / 12期

基金：

美国国家卫生研究院;

关键词：

endogenous DNA damage; homology-directed DNA repair; chromosome segregation; Escherichia coli; genome integrity; DNA replication; SSB single-strand binding protein; RecG; mutations; evolution; STRESS-INDUCED MUTAGENESIS; RECOMBINATION; PROTEIN; REPLICATION; RECG;

D O I：

10.1128/jb.00272-23

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this issue of the Journal of Bacteriology, N. J. Bonde, E. A. Wood, K. S. Myers, M. Place, J. L. Keck, and M. M. Cox (J Bacteriol 205:e00184-23, 2023, https//doi.org/10.1128/jb.00184-23) used an unbiased transposon-sequencing (Tn-seq) screen to identify proteins required for life when cells lose the RecG branched-DNA helicase (synthetic lethality). The proteins' identities indicate pathways that prevent endogenous DNA damage, pathways that prevent its homology-directed repair (HDR) "strand-exchange" intermediates between sister chromosomes, and pathways that resolve those intermediates. All avoid intermediate pile-up, which blocks chromosome segregation, causing "death-by-recombination." DNA damage is managed to regulate crucial but potentially lethal HDR.

引用

页数：5

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