Biochemical analysis based on optical detection integrated microfluidic chip

被引：34
|
作者：
Wei, Yu-Jia [1 ]
Zhao, Ya-Nan [1 ]
Zhang, Xuan [1 ]
Wei, Xing [1 ]
Chen, Ming-Li [1 ]
Chen, Xu-Wei [1 ]
机构：
[1] Northeastern Univ, Dept Chem, Coll Sci, Res Ctr Analyt Sci, Box 332, Shenyang 110819, Peoples R China
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2023年 / 158卷
基金：
中国国家自然科学基金;
关键词：
Microfluidic chip; Optical detection; Biochemical analysis; UV-Vis absorption; Fluorescence; Infrared; Surface plasmon resonance; Chemiluminescence; Optical tweezers; SINGLE-CELL ANALYSIS; ON-A-CHIP; STEM-CELL; LABEL-FREE; FLUORESCENCE; DEVICE; FLOW; PROTEIN; BIOSENSORS; SYSTEMS;
D O I：
10.1016/j.trac.2022.116865
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Nowadays, biochemical analysis such as cell analysis, disease diagnosis and treatment, environmental monitoring and food safety are gaining increasing attention. Optically integrated microfluidic technology exhibits the merits of high sensitivity, fast detection, and great selectivity, in which flexible optical detection techniques could be easily adopted according to the unique design of microfluidic structure and screening analysis of various scales could be readily realized based on the precisely-controlled fluidics, achieving the high throughput analysis, miniaturized reagent consumption and reduced assay expenditure. In this review, the integration of microfluidic chips with optical detection techniques (UV eVis absorption, fluorescence, infrared, surface plasmon resonance, chemiluminescence and optical tweezers), and its application in biochemical analysis are introduced, and the future development prospects of optically integrated microfluidic chips are prospected. (c) 2022 Elsevier B.V. All rights reserved.
引用
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页数：14
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