Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants

被引:7
|
作者
Zhang, Xinjuan [1 ]
Xie, Weiwei [2 ]
Du, Wenrui [3 ]
Liu, Yanqiu [1 ]
Lin, Jianzhong [4 ]
Yin, Wu [5 ]
Yang, Lihui [6 ]
Yuan, Fengjuan [1 ]
Zhang, Ran [1 ]
Liu, Haipeng [7 ]
Ma, Hailin [2 ]
Zhang, Jiaxing [1 ]
机构
[1] Xiamen Univ, Inst Brain Dis & Cognit, Sch Med, Xiamen 361102, Peoples R China
[2] Tibet Univ, Plateau Brain Sci Res Ctr, Lhasa 850012, Peoples R China
[3] Xiamen Univ, Sch Med, Dept Clin Med, Xiamen 361102, Peoples R China
[4] Xiamen Univ, Zhongshan Hosp, Sch Med, Dept Radiol, Xiamen 361102, Peoples R China
[5] Tibet Autonomous Reg Peoples Hosp, Dept Radiol, Lhasa 850000, Tibet Autonomou, Peoples R China
[6] Tibet Autonomous Reg Peoples Hosp, Dept Endocrinol, Lhasa 850000, Tibet Autonomou, Peoples R China
[7] Tibet Autonomous Reg Womens & Childrens Hosp, Dept Radiol, Lhasa 850000, Tibet Autonomou, Peoples R China
基金
中国国家自然科学基金;
关键词
High altitude; Tibetans; Hypoxia; Brain structure; Brain functional networks; CORTICAL THICKNESS; ADAPTATION; ORGANIZATION; PERFORMANCE;
D O I
10.1007/s11682-023-00759-5
中图分类号
R445 [影像诊断学];
学科分类号
100207 ;
摘要
It has been well-established that high-altitude (HA) environments affect the human brain; however, the differences in brain structural and functional networks between HA natives and acclimatized immigrants have not been well clarified. In this study, native HA Tibetans were recruited for comparison with Han immigrants (average of 2.3 +/- 0.3 years at HA), with lowland residents recruited as controls. Cortical gray matter volume, thickness, and functional connectivity were investigated using magnetic resonance imaging data. In addition, reaction time and correct score in the visual movement task, hematology, and SpO(2) were measured. In both Tibetans and HA immigrants vs. lowlanders, decreased SpO(2), increased hematocrit and hemoglobin, and increased reaction time and correct score in the visual movement task were detected. In both Tibetans and HA immigrants vs. lowlanders, gray matter volumes and cortical thickness were increased in the left somatosensory and motor cortex, and functional connectivity was decreased in the visual, default mode, subcortical, somatosensory-motor, ventral attention, and subcortical networks. Furthermore, SpO(2) increased, hematocrit and hemoglobin decreased, and gray matter volumes and cortical thickness increased in the visual cortex, left motor cortex, and right auditory cortex in native Tibetans compared to immigrants. Movement time and correct score in task were positively correlated with the thickness of the visual cortex. In conclusion, brain structural and functional network difference in both Tibetan natives and HA immigrants were largely consistent, with native Tibetans only showing more intense brain modulation. Different populations acclimatized to HA develop similar brain mechanisms to cope with hostile HA environmental factors.
引用
收藏
页码:271 / 281
页数:11
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