Visible-Light-Induced Multicomponent Synthesis of Tetrasubstituted Imidazoles

被引：3
|
作者：
Borkotoky, Lodsna [1 ,2 ]
Bora, Kaushik [1 ,2 ]
Maurya, Ram Awatar [1 ,2 ]
机构：
[1] North East Inst Sci & Technol NEIST, CSIR, Chem Sci & Technol Div, Appl Organ Chem Grp, Jorhat 785006, Assam, India
[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, Uttar Pradesh, India
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 05期
关键词：
2; 4-Dinitrophenol; Imidazole; Multicomponent reaction; Photocatalysis; Visible light; OXIDATIVE COUPLING REACTION; ALPHA-AMINOPHOSPHONATES; BIOLOGICAL EVALUATION; PHOTOREDOX CATALYSIS; AMIDINES SYNTHESIS; VINYL AZIDES; AMINES; ALDEHYDES/KETONES; CYCLIZATION;
D O I：
10.1002/ajoc.202300146
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient visible light photocatalyzed one-pot, three-component synthesis of tetrasubstituted imidazoles was developed. Catalytic amount of 2,4-dinitrophenol (2,4-DNP) was necessary for the successful coupling of anilines, aldehydes and alpha-keto vinyl azides to yield imidazoles in the presence of 7 W blue LED light. The scope of the reaction was demonstrated by synthesizing a series of highly functionalized imidazoles in excellent yields (75-86%). Control experiments were carried out and a mechanistic rationalization of the three-component reaction was proposed.
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页数：4
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