Dendritic cells in liver transplantation immune response

被引：3
|
作者：
Du, Xiaodong [1 ]
Li, Mingqian [1 ]
Huan, Chen [2 ]
Lv, Guoyue [1 ]
机构：
[1] First Hosp Jilin Univ, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Changchun, Peoples R China
[2] First Hosp Jilin Univ, Inst Virol & AIDS Res, Ctr Infect Dis & Pathogen Biol, Key Lab Organ Regenerat & Transplantat,Minist Educ, Changchun, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷
基金：
中国国家自然科学基金;
关键词：
liver transplantation; dendritic cells; immune rejection; immune tolerance; DC based treatment; CARDIAC ALLOGRAFT SURVIVAL; COLONY-STIMULATING FACTOR; REGULATORY T-CELL; INDOLEAMINE 2,3-DIOXYGENASE; LYMPH-NODES; IN-VIVO; ALLOSTIMULATORY FUNCTION; TUMOR-IMMUNOTHERAPY; ACUTE REJECTION; STEADY-STATE;
D O I：
10.3389/fcell.2023.1277743
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Dendritic cells (DCs) are the most powerful antigen presenting cells (APCs), they are considered one of the key regulatory factors in the liver immune system. There is currently much interest in modulating DC function to improve transplant immune response. In liver transplantation, DCs participate in both the promotion and inhibition of the alloreponse by adopting different phenotypes and function. Thus, in this review, we discussed the origin, maturation, migration and pathological effects of several DC subsets, including the conventional DC (cDC), plasmacytoid DC (pDC) and monocyte-derived DC (Mo-DC) in liver transplantation, and we summarized the roles of these DC subsets in liver transplant rejection and tolerance. In addition, we also outlined the latest progress in DC-based related treatment regimens. Overall, our discussion provides a beneficial resource for better understanding the biology of DCs and their manipulation to improve the immune adaptability of patients in transplant status.
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收藏
页数：14
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