Research Progress of Long Non-coding RNAs in Spinal Cord Injury

被引：5
|
作者：
Cai, Zongyan [1 ]
Han, Xue [1 ]
Li, Ruizhe [1 ]
Yu, Tianci [1 ]
Chen, Lei [1 ]
Wu, XueXue [1 ]
Jin, Jiaxin [1 ,2 ,3 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Gansu, Peoples R China
[2] Orthopaed Key Lab Gansu Prov, Lanzhou 730000, Peoples R China
[3] Lanzhou Univ, Dept Orthopaed, Hosp 2, Lanzhou 730000, Peoples R China
来源：
NEUROCHEMICAL RESEARCH | 2023年 / 48卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Spinal cord injury; LncRNA; Genetic analysis; Inflammatory response; Apoptosis; Nerve repair; INFLAMMATORY RESPONSE; NEUROPATHIC PAIN; REGENERATION; INHIBITION; EXPRESSION; KNOCKDOWN; RECOVERY; RELIEVES; CELLS; RATS;
D O I：
10.1007/s11064-022-03720-y
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Spinal cord injury (SCI) can result in a partial or complete loss of motor and sensory function below the injured segment, which has a significant impact on patients' quality of life and places a significant social burden on them. Long non-coding RNA (LncRNA) is a 200-1000 bp non-coding RNA that has been shown to have a key regulatory role in the progression of a variety of neurological illnesses. Many studies have demonstrated that differentially expressed LncRNAs following spinal cord injury can participate in inflammatory damage, apoptosis, and nerve healing by functioning as competitive endogenous RNA (ceRNA); at the same time, it has a significant regulatory effect on sequelae such neuropathic pain. As a result, we believe that LncRNAs could be useful as a molecular regulatory target in the diagnosis, treatment, and prognosis of spinal cord injury.
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页码：1 / 12
页数：12
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