Reduction of mycophenolate mofetil dosage to limit prolonged viral shedding in solid organ transplant recipients with COVID-19: Two case reports

被引：0

作者：

Murai, Yushi ^{[1
,4
]}

Sakao, Seiichiro ^{[1
]}

Kure, Fujihiro ^{[1
]}

Kawasaki, Takeshi ^{[1
]}

Maruyama, Michihiro ^{[2
]}

Suzuki, Hidemi ^{[3
]}

Yoshino, Ichiro ^{[3
]}

Suzuki, Takuji ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Respirol, Chiba 2608670, Japan

[2] Chiba Univ, Grad Sch Med, Dept Esophageal Gastro Intestinal Surg, Chiba 2608670, Japan

[3] Chiba Univ, Grad Sch Med, Dept Gen Thorac Surg, Chiba 2608670, Japan

[4] Chiba Univ, Grad Sch Med, Dept Respirol, 1 Inohana Chuo Ku, Chiba 2608670, Japan

来源：

RESPIRATORY INVESTIGATION | 2024年 / 62卷 / 01期

关键词：

COVID-19; Mycophenolic acid; Lung transplantation; Kidney transplantation; CULTURES;

D O I：

10.1016/j.resinv.2023.10.006

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Solid organ transplant (SOT) recipients with coronavirus disease-2019 (COVID-19) experience prolonged viral shedding, and they are forced to stay in the hospital because of the requirement for COVID-19 isolation. Here, we present two cases (lung and renal transplant recipients), wherein the isolation period was shortened by reducing the dosage of mycophenolate mofetil (MMF). Both patients recovered well from COVID-19 pneumonia. This case study suggests that a reduction in MMF dosage may lead to a shorter hospitalization period in SOT recipients with COVID-19.

引用

页码：98 / 101

页数：4

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