Current Advances of Mitochondrial Dysfunction and Cardiovascular Disease and Promising Therapeutic Strategies

被引：10

作者：

Xia, Dexiang ^{[1
]}

Liu, Yue ^{[1
]}

Wu, Peng ^{[2
]}

Wei, Dangheng ^{[1
,3
]}

机构：

[1] Univ South China, Hengyang Med Sch, Hunan Int Sci & Technol Cooperat Base Arterioscler, Inst Cardiovasc Dis,Key Lab Arteriosclerol Hunan P, Hengyang, Peoples R China

[2] Hengyang Maternal & Child Hlth Hosp, Hengyang, Peoples R China

[3] Univ South China, Hengyang 421001, Hunan, Peoples R China

来源：

AMERICAN JOURNAL OF PATHOLOGY | 2023年 / 193卷 / 10期

基金：

中国国家自然科学基金;

关键词：

ELECTRON-TRANSPORT CHAIN; ISCHEMIA-REPERFUSION INJURY; DNA COPY NUMBER; OXIDATIVE STRESS; HEART-FAILURE; DOUBLE-BLIND; MYOCARDIAL-ISCHEMIA; DOWN-REGULATION; KETONE-BODIES; BIOGENESIS;

D O I：

10.1016/j.ajpath.2023.06.013

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Mitochondria are cellular power stations and essential organelles for maintaining cellular homeostasis. Dysfunctional mitochondria have emerged as a key factor in the occurrence and development of car-diovascular disease. This review focuses on advances in the relationship between mitochondrial dysfunction and cardiovascular diseases such as atherosclerosis, heart failure, myocardial ischemia reperfusion injury, and pulmonary arterial hypertension. The clinical value and challenges of mitochondria-targeted strategies, including mitochondria-targeted antioxidants, mitochondrial quality control modulators, mitochondrial function protectors, mitochondrial biogenesis promoters, and recently developed mitochondrial transplants, are also discussed. (Am J Pathol 2023,

引用

页码：1485 / 1500

页数：16

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