Preparation, Physicochemical Properties, and Structural Characterization of Resistant Starch-Aspirin-Loaded Microspheres

Background: Resistant starch is a novel type of dietary fiber that can be considered as a natural polymer carrier with poten-tial development prospects in the field of oral colonic release preparations since it can be degraded by bacte-ria in the large intestine.Material/Methods: In this study, oral resistant starch-drug-loaded microspheres were prepared by spraydrying, and the response surface method was used to optimize the process based on the encapsulation efficiency.Results: The optimal preparation process conditions for the resistant starch-aspirin-loaded microspheres were as fol-lows: core material: wall material ratio of 1: 1.98, chitosan solution concentration of 1.98%, and spray drying air inlet temperature of 130.45 & DEG;C resulted in a reliable entrapment efficiency of 68.96%. Infrared spectroscopy analysis indicated that the encapsulated aspirin-starch microspheres did not differ significantly from the origi-nal resistant starch material. The ultrastructure of the drug-loaded microspheres was evenly wrapped with the capsule core and appeared as smooth spheres. The combination of resistant starch, aspirin, and chitosan re-sulted in a cross-linking reaction that reduced the overall gelatinization temperature compared with the orig-inal starch material alone. The light transmittance of the drug-loaded microspheres was slightly higher than that of the original resistant starch, while digestibility was similar to that of the resistant starch, indicating that the release would exist in the environment of the large intestine.Conclusions: This study provides pivotal insights into the development of resistant starch in the field of colonic release preparations.