Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements

被引:16
|
作者
Krupina, Ksenia [1 ]
Goginashvili, Alexander [1 ]
Cleveland, Don W. [1 ]
机构
[1] Univ Calif San Diego, Dept Cellular & Mol Med, La Jolla, CA 92093 USA
关键词
ACUTE MYELOID-LEUKEMIA; CYCLIC GMP-AMP; DNA-DAMAGE; MUTATIONAL SIGNATURES; UTERINE LEIOMYOMAS; CHROMOTHRIPSIS; EVOLUTION; ABNORMALITIES; MICRONUCLEI; MECHANISMS;
D O I
10.1038/s41576-023-00663-0
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencing of human tumours, the most frequent type of complex chromosome rearrangement is chromothripsis, a massive, localized and clustered rearrangement of one (or a few) chromosomes seemingly acquired in a single event. Chromothripsis can be initiated by mitotic errors that produce a micronucleus encapsulating a single chromosome or chromosomal fragment. Rupture of the unstable micronuclear envelope exposes its chromatin to cytosolic nucleases and induces chromothriptic shattering. Found in up to half of tumours included in pan-cancer genomic analyses, chromothriptic rearrangements can contribute to tumorigenesis through inactivation of tumour suppressor genes, activation of proto-oncogenes, or gene amplification through the production of self-propagating extrachromosomal circular DNAs encoding oncogenes or genes conferring anticancer drug resistance. Here, we discuss what has been learned about the mechanisms that enable these complex genomic rearrangements and their consequences in cancer. Chromothripsis, a complex genomic rearrangement of one (or a few) chromosomes, is frequently found in cancer genomes. The authors review methods to identify chromothripsis in cancer genomes and discuss its mechanisms of formation in micronuclei or chromosomal bridges as well as its consequences in cancer. They also highlight the link between chromothripsis and extrachromosomal DNA.
引用
收藏
页码:196 / 210
页数:15
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