targeted therapy;
turnaround time;
health economic analysis;
hospital costs;
genetic testing;
return on investment;
D O I:
10.36469/jheor.2023.77686
中图分类号:
F [经济];
学科分类号:
02 ;
摘要:
Background: Targeted therapy for cancer is becoming more frequent as the understanding of the molecular pathogenesis increases. Molecular testing must be done to use targeted therapy. Unfortunately, the testing turnaround time can delay the initiation of targeted therapy. Objective: To investigate the impact of a next-generation sequencing (NGS) machine in the hospital that would allow for in-house NGS testing of metastatic non-small cell lung cancer (mNSCLC) in a US setting. Methods: The differences between 2 hospital pathways were established with a cohort-level decision tree that feeds into a Markov model. A pathway that used in-house NGS (75%) and the use of external laboratories (so-called send-out NGS) (25%), was compared with the standard of exclusively send-out NGS. The model was from the perspective of a US hospital over a 5-year time horizon. All cost input data were in or inflated to 2021 USD. Scenario analysis was done on key variables. Results: In a hospital with 500 mNSCLC patients, the implementation of in-house NGS was estimated to increase the testing costs and the revenue of the hospital. The model predicted a $710 060 increase in testing costs, a $1 732 506 increase in revenue, and a $1 022 446 return on investment over 5 years. The payback period was 15 months with in-house NGS. The number of patients on targeted therapy increased by 3.38%, and the average turnaround time decreased by 10 days when in-house NGS was used. Discussion: Reducing testing turnaround time is a benefit of in-house NGS. It could contribute to fewer mNSCLC patients lost to second opinion and an increased number of patients on targeted therapy. The model outcomes predicted that, over a 5-year period, there would be a positive return on investment for a US hospital. The model reflects a proposed scenario. The heterogeneity of hospital inputs and the cost of send-out NGS means context-specific inputs are needed. Conclusion: Using in-house NGS testing could reduce the testing turnaround time and increase the number of patients on targeted therapy. Additional benefits for the hospital are that fewer patients will be lost to second opinion and that in-house NGS could generate additional revenue.
机构:
Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R ChinaQueen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
Fong, A. H. W.
Lau, E. Y. T.
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Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R ChinaQueen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
Lau, E. Y. T.
Cheung, W. K. C.
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机构:
DiagCor Biosci Incorp Ltd, Kowloon, Hong Kong, Peoples R ChinaQueen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
Cheung, W. K. C.
Cho, W. C. S.
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机构:
Queen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R ChinaQueen Elizabeth Hosp, Dept Clin Oncol, Kowloon, Hong Kong, Peoples R China
机构:
Mohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
El Zaitouni, Sara
Laraqui, Abdelilah
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Mohammed V Univ Rabat, Mohammed V Mil Instruct Hosp, Fac Med & Pharm, Ctr Virol Infect & Trop Dis,Lab Virol,Sequencing, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Laraqui, Abdelilah
Ghaouti, Meriem
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机构:
Nations Unites Pathol Ctr, Dept Pathol, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Ghaouti, Meriem
Benzekri, Asmae
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Nations Unites Pathol Ctr, Dept Pathol, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Benzekri, Asmae
Kettani, Fouad
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Nations Unites Pathol Ctr, Dept Pathol, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Kettani, Fouad
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Boustany, Youssra
Benmokhtar, Soukaina
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Mohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Benmokhtar, Soukaina
Alaoui, Hafsa Lamrani
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Mohammed V Univ Rabat, Fac Med & Pharm, Lab Microbiol, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Alaoui, Hafsa Lamrani
El Annaz, Hicham
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Mohammed V Univ Rabat, Mohammed V Mil Instruct Hosp, Fac Med & Pharm, Ctr Virol Infect & Trop Dis,Lab Virol,Sequencing, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
El Annaz, Hicham
Abi, Rachid
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Mohammed V Univ Rabat, Mohammed V Mil Instruct Hosp, Fac Med & Pharm, Ctr Virol Infect & Trop Dis,Lab Virol,Sequencing, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Abi, Rachid
Tagajdid, Mohamed Rida
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Mohammed V Univ Rabat, Mohammed V Mil Instruct Hosp, Fac Med & Pharm, Ctr Virol Infect & Trop Dis,Lab Virol,Sequencing, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Tagajdid, Mohamed Rida
El Kochri, Safae
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Mohammed V Univ Rabat, Mohammed V Mil Instruct Hosp, Fac Med & Pharm, Ctr Virol Infect & Trop Dis,Lab Virol,Sequencing, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
El Kochri, Safae
El Mchichi, Bouchra
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Mohammed V Univ Rabat, Mohammed V Mil Instruct Hosp, Fac Med & Pharm, Ctr Virol Infect & Trop Dis,Lab Virol,Sequencing, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
El Mchichi, Bouchra
Bouaiti, El Arbi
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Mohammed V Univ Rabat, Fac Med & Pharm, Lab Biostat Clin Res & Epidemiol, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Bouaiti, El Arbi
Lahlou, Idriss Amine
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Mohammed V Univ Rabat, Mohammed V Mil Instruct Hosp, Fac Med & Pharm, Ctr Virol Infect & Trop Dis,Lab Virol,Sequencing, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
Lahlou, Idriss Amine
El Hassani, Rabii Ameziane
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Mohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco
El Hassani, Rabii Ameziane
Ennibi, Khalid
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Mohammed V Univ Rabat, Mohammed V Mil Instruct Hosp, Fac Med & Pharm, Ctr Virol Infect & Trop Dis,Lab Virol,Sequencing, Rabat, MoroccoMohammed V Univ Rabat, Fac Sci, Genom Ctr Human Pathol, Dept Biol, 4 Ibn Batouta Ave, MB 1014, Rabat 10000, Morocco