Population Pharmacokinetic and Pharmacodynamic Analyses of Obexelimab in Healthy Volunteers and in Patients with Rheumatoid Arthritis or IgG4-Related Diseases

被引：0
|
作者：
Wang, Xiaodong [1 ]
Kirk, Rachel [1 ]
Hua, Simon Lowry [1 ]
机构：
[1] Zenas BioPharma, Waltham, MA USA
来源：
ARTHRITIS & RHEUMATOLOGY | 2023年 / 75卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
0002
引用
收藏
页码：2 / 3
页数：2
相关论文
共 50 条
  • [41] POPULATION PHARMACOKINETIC/PHARMACODYNAMIC (PKPD) ANALYSIS OF EPO DURING DAPRODUSTAT TREATMENT IN HEALTHY VOLUNTEERS (HV) AND CHRONIC KIDNEY DISEASE (CKD) PATIENTS WITH ANEMIA.
    Snelder, N.
    Post, T.
    van den Berg, P.
    Hooijmaijers, R.
    Ahsman, M.
    Vasist, L.
    Mahar, K.
    Visser, S.
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2021, 109 : S15 - S15
  • [42] Exposure-efficacy assessment of golimumab in patients with active rheumatoid arthritis despite methotrexate therapy: Application of population Pharmacokinetic/Pharmacodynamic modeling.
    Zhou, H.
    Xu, Z.
    Rahman, M. U.
    Wagner, C.
    Pendley, C.
    Han, J.
    Baker, D.
    Jang, H.
    Davis, H. M.
    ARTHRITIS AND RHEUMATISM, 2006, 54 (09): : S418 - S418
  • [43] A Population Pharmacokinetic Assessment of the Effect of Food on Selumetinib in Patients with Neurofibromatosis Type 1-Related Plexiform Neurofibromas and Healthy Volunteers
    Zuo, Peiying
    Arefayene, Million
    Pan, Wei-Jian
    Freshwater, Tomoko
    Monteleone, Jonathan
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2024, 13 (07): : 770 - 781
  • [44] IgG4-related disease in patients with newly diagnosed idiopathic retroperitoneal fibrosis: a population-based Danish study
    Lomborg, N.
    Jakobsen, M.
    Bode, C. S.
    Junker, P.
    SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, 2019, 48 (04) : 320 - 325
  • [45] Evaluation of the safety, efficacy, and mechanism of action of obexelimab for the treatment of patients with IgG4-related disease: an open-label, single-arm, single centre, phase 2 pilot trial
    Perugino, Cory A.
    Wallace, Zachary S.
    Zack, Debra J.
    Quinn, Shauna M.
    Poma, Allen
    Fernandes, Ana
    Foster, Paul
    DeMattos, Steve
    Burington, Bart
    Liu, Hang
    Allard-Chamard, Hugues
    Smith, Nathan
    Kai, Xin
    Xing, Kelly
    Pillai, Shiv
    Stone, John H.
    LANCET RHEUMATOLOGY, 2023, 5 (08): : E442 - E450
  • [46] One patient, one immune system, and three independent immunological diseases: IgG4-related systemic disease, rheumatoid arthritis, and CSF3R-negative chronic neutrophilic leukaemia
    Christoph, S.
    Grammon, N.
    Gerken, G.
    Lange, C.
    Kahraman, A.
    ONCOLOGY RESEARCH AND TREATMENT, 2021, 44 : 163 - 163
  • [47] Analysis of pancreatic endocrine function in patients with IgG4-related diseases, in whom autoimmune pancreatitis was ruled out by diagnostic imaging
    Ito, Naoko
    Yagi, Kunimasa
    Kawano, Mitsuhiro
    Mori, Yukiko
    Okazaki, Satoko
    Chujo, Daisuke
    Takeda, Yoshiyu.
    Kobayashi, Junji
    Yamagishi, Masakazu
    ENDOCRINE JOURNAL, 2014, 61 (08) : 765 - 772
  • [48] Population pharmacokinetic-pharmacodynamic (PK-PD) modeling of etanercept in patients with juvenile rheumatoid arthritis (JRA) using a dichotomous clinical endpoint.
    Yim, D
    Zhou, H
    Peck, CC
    Lee, H
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2005, 77 (02) : P92 - P92
  • [49] A case of IgG4-related disease presented with Kimura disease-like skin eruption, rheumatoid arthritis-like abnormality and interstitial pneumonia
    Kotani, H.
    Ohtsuka, T.
    Okada, S.
    Kusama, M.
    Taniguchi, T.
    CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2020, 45 (06) : 733 - 734
  • [50] Population pharmacokinetics of adalimumab biosimilar adalimumab-adbm and reference product in healthy subjects and patients with rheumatoid arthritis to assess pharmacokinetic similarity
    Kang, Jia
    Eudy-Byrne, Rena J.
    Mondick, John
    Knebel, William
    Jayadeva, Girish
    Liesenfeld, Karl-Heinz
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2020, 86 (11) : 2274 - 2285
12345