Human leukocyte immunoglobulin-like receptors in health and disease

被引:14
|
作者
Redondo-Garcia, Silvia [1 ]
Barritt, Christopher [1 ,2 ,3 ]
Papagregoriou, Charys [1 ,6 ]
Yeboah, Muchaala [1 ]
Frendeus, Bjorn [1 ,4 ]
Cragg, Mark S. [1 ,5 ]
Roghanian, Ali [1 ,5 ]
机构
[1] Univ Southampton, Sch Canc Sci, Antibody & Vaccine Grp, Ctr Canc Immunol,Fac Med,Southampton Gen Hosp, Southampton, England
[2] Glasgow Royal Infirm, Lister Dept Gen Surg, Glasgow, Scotland
[3] Univ Glasgow, Sch Med Dent & Nursing, Glasgow, Scotland
[4] BioInvent Int AB, Lund, Sweden
[5] Univ Southampton, Inst Life Sci, Southampton, England
[6] Ctr Study Haematol & Other Malignancies, Nicosia, Cyprus
来源
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金
英国生物技术与生命科学研究理事会; 英国医学研究理事会;
关键词
LILR; immune tolerance; cancer; autoimmunity; infection; immunomodulation; immunotherapy; MHC CLASS-I; SOLUBLE HLA-G; T-SUPPRESSOR-CELLS; ANTIGEN-PRESENTING CELLS; TOLEROGENIC ENDOTHELIAL-CELLS; PLASMACYTOID DENDRITIC CELLS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACUTE MYELOID-LEUKEMIA; NATURAL-KILLER-CELLS; VERSUS-HOST-DISEASE;
D O I
10.3389/fimmu.2023.1282874
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human leukocyte immunoglobulin (Ig)-like receptors (LILR) are a family of 11 innate immunomodulatory receptors, primarily expressed on lymphoid and myeloid cells. LILRs are either activating (LILRA) or inhibitory (LILRB) depending on their associated signalling domains (D). With the exception of the soluble LILRA3, LILRAs mediate immune activation, while LILRB1-5 primarily inhibit immune responses and mediate tolerance. Abnormal expression and function of LILRs is associated with a range of pathologies, including immune insufficiency (infection and malignancy) and overt immune responses (autoimmunity and alloresponses), suggesting LILRs may be excellent candidates for targeted immunotherapies. This review will discuss the biology and clinical relevance of this extensive family of immune receptors and will summarise the recent developments in targeting LILRs in disease settings, such as cancer, with an update on the clinical trials investigating the therapeutic targeting of these receptors.
引用
收藏
页数:29
相关论文
共 50 条
  • [21] Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on Chromosome 19q13.4
    Liu, WR
    Kim, J
    Nwankwo, C
    Ashworth, LK
    Arm, JP
    IMMUNOGENETICS, 2000, 51 (8-9) : 659 - 669
  • [22] Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on Chromosome 19q13.4
    W. Robert Liu
    Joomyeong Kim
    Chioma Nwankwo
    Linda K. Ashworth
    J. P. Arm
    Immunogenetics, 2000, 51 : 659 - 669
  • [23] Diversity of Killer Cell Check for Immunoglobulin-Like Receptors and Disease
    Rajalingam, Raja
    CLINICS IN LABORATORY MEDICINE, 2018, 38 (04) : 637 - +
  • [24] Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7
    Tedla, N
    Bandeira-Melo, C
    Tassinari, P
    Sloane, DE
    Samplaski, M
    Cosman, D
    Borges, L
    Weller, PF
    Arm, JP
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (03) : 1174 - 1179
  • [25] DNA extraction from coagulated human blood for application in genotyping techniques for human leukocyte antigen and immunoglobulin-like receptors
    Cardozo, Daniela Maira
    Guelsin, Glaucia Andreia
    Clementino, Samaia Laface
    de Melo, Fabiano Cavalcante
    Braga, Marco Antonio
    de Souza, Cleonice
    Moliterno, Ricardo Alberto
    Laguila Visentainer, Jeane Eliete
    REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 2009, 42 (06) : 651 - 656
  • [26] Characterization of the human homologues of murine paired immunoglobulin-like receptors
    Hurez, V
    Tun, T
    Cooper, MD
    Burrows, PD
    Kubagawa, H
    FASEB JOURNAL, 1998, 12 (05): : A1076 - A1076
  • [27] Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer
    Cornillet, Martin
    Jansson, Hannes
    Schaffer, Marie
    Hertwig, Laura
    Berglin, Lena
    Zimmer, Christine L.
    Johansson, Helene
    Ellis, Ewa
    Isaksson, Bengt
    Gonzalez-Galarza, Faviel F.
    Middleton, Derek
    Malmberg, Karl-Johan
    Sparrelid, Ernesto
    Bjorkstrom, Niklas K.
    GASTROENTEROLOGY, 2019, 157 (04) : 1067 - +
  • [28] Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis
    Fialho, Raquel Nunes
    Martins, Luis
    Pinheiro, Joao Paulo
    Bettencourt, Bruno Filipe
    Couto, Ana Rita
    Santos, Margarida Rodrigues
    Peixoto, Maria Jose
    Garrett, Francisco
    Leal, Joao
    Tomas, Ana Maria
    Bruges-Armas, Jacome
    HUMAN IMMUNOLOGY, 2009, 70 (11) : 915 - 920
  • [29] Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors
    Kang, Xunlei
    Kim, Jaehyup
    Deng, Mi
    John, Samuel
    Chen, Heyu
    Wu, Guojin
    Phan, Hiep
    Zhang, Cheng Cheng
    CELL CYCLE, 2016, 15 (01) : 25 - 40
  • [30] The emerging role of leukocyte immunoglobulin-like receptors (LILRs) in HIV-1 infection
    Lichterfeld, Mathias
    Yu, Xu G.
    JOURNAL OF LEUKOCYTE BIOLOGY, 2012, 91 (01) : 27 - 33