Metallomic Signatures of Lung Cancer and Chronic Obstructive Pulmonary Disease

被引：2

作者：

Callejon-Leblic, Belen ^{[1
]}

Espirilla, Saida Sanchez ^{[1
,2
]}

Gotera-Rivera, Carolina ^{[3
]}

Santana, Rafael ^{[3
]}

Diaz-Olivares, Isabel ^{[4
]}

Marin, Jose M. ^{[5
]}

Macario, Ciro Casanova ^{[6
]}

Cosio, Borja Garcia ^{[7
]}

Fuster, Antonia ^{[8
]}

Garcia, Ingrid Solanes ^{[9
]}

de-Torres, Juan P. ^{[10
]}

Collado, Nuria Feu ^{[11
]}

Lopez, Carlos Cabrera ^{[12
]}

Diago, Carlos Amado ^{[13
]}

Plaza, Amparo Romero ^{[14
]}

Fraysse, Luis Alejandro Padron ^{[15
]}

Marquez Martin, Eduardo ^{[16
]}

Royo, Margarita Marin ^{[17
]}

Vilarnau, Eva Balcells ^{[18
]}

Casanovas, Antonia Llunell ^{[19
]}

Gonzalez, Cristina Martinez ^{[20
]}

Iturri, Juan Bautista Galdiz ^{[21
]}

Bautista, Celia Lacarcel ^{[22
]}

Gomez-Ariza, Jose Luis ^{[1
]}

Pereira-Vega, Antonio ^{[15
]}

Seijo, Luis ^{[23
]}

Lopez-Campos, Jose Luis ^{[24
,25
]}

Peces-Barba, German ^{[3
]}

Garcia-Barrera, Tamara ^{[1
]}

机构：

[1] Univ Huelva, Fac Expt Sci, Res Ctr Nat Resources Hlth & Environm RENSMA, Dept Chem, Campus El Carmen,Fuerzas Armadas Ave, Huelva 21007, Spain

[2] Natl Univ San Antonio Abad Cusco, Fac Sci, Dept Chem, Ave Cultura, Cuzco 773, Peru

[3] ISCIII CIBERES, IIS Jimenez Diaz Fdn, Reyes Catolicos Ave, Madrid 28040, Spain

[4] Beturia Andalusian Fdn Hlth Res FABIS, Ronda Norte S-N, Huelva 21005, Spain

[5] Miguel Servet Hosp IIS Aragon, ISCIII CIBERES, Paseo Isabel Catolica, 1-3, Zaragoza 50009, Spain

[6] Univ La Laguna, Hosp Univ Nuestra Senora Candelaria, Pulm Dept, Res Unit,CIBERES,ISCIII, Padre Herrera S-N, Santa Cruz de Tenerife 38200, Spain

[7] Son Espases Hosp, IdISBa, ISCIII CIBERES, Valldemossa Rd 79, Palma De Mallorca 07120, Spain

[8] Son Llatzer Hosp, C Manacor, Palma De Mallorca 07198, Spain

[9] Santa Creu i St Pau Hosp, Carrer St Antoni Maria Claret 167, Barcelona 08025, Spain

[10] Univ Clin Navarra, Pio 12Ave, 36, Pamplona 31008, Spain

[11] Reina Sofia Hosp, Maimonides Inst Biomed Res Cordoba, Menendez Pidal Ave, S-N, Cordoba 14004, Spain

[12] Univ Hosp Gran Canaria Dr Negrin, Resp Serv, C Pl Barranco Ballena, s-n, Las Palmas Gran Canaria 35010, Spain

[13] Valdecilla Hosp, Valdecilla S-N, Santander 39008, Spain

[14] Manacor Hosp, Manacor Alcudia Rd S-N, Manacor 07500, Spain

[15] Juan Ramon Jimenez Hosp, Pneumol Area, Ronda Norte S-N, Huelva 21005, Spain

[16] Virgen Rocio Hosp, Inst Biomed Seville IBiS, ISCIII CIBERES, Manuel Siurot Ave S-N, Seville 41013, Spain

[17] Castellon Hosp, Benicassim Ave, 128, Castellon de La Plana 12004, Spain

[18] Hosp Mar, ISCIII CIBERES, Paseo Maritimo Barceloneta, 25, 29, Barcelona 08003, Spain

[19] Terrassa Hosp, Torrebon Rd, S-N, Barcelona 08227, Spain

[20] Cent Hosp Asturias, Dept Cardiol, Roma Ave, S-N, Oviedo 33011, Spain

[21] Cruces Univ Hosp, ISCIII CIBERES, Cruces Plaza, S-N, Baracaldo 48903, Spain

[22] Jaen Univ Hosp, Ave Ejercito Espanol 10, Jaen 23007, Spain

[23] Univ Clin Navarra, ISCIII CIBERES, Monforte Lemos Ave, Madrid 28029, Spain

[24] Univ Seville, Virgen Rocio Univ Hosp, Inst Biomed Seville IBiS, Med Surg Unit Resp Dis, Manuel Siurot Ave, S-N, Seville 41013, Spain

[25] Carlos III Hlth Inst, Ctr Biomed Res Resp Dis Network CIBERES, Ave Monforte Lemos, 3-5, Madrid 28029, Spain

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 18期

关键词：

lung cancer; chronic obstructive pulmonary disease; metals; inductively coupled plasma; metallomics; mass spectrometry; HEAVY-METALS; ESTROGEN-RECEPTOR; SERUM; IRON; STRESS; PLASMA; IONS;

D O I：

10.3390/ijms241814250

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.

引用

页数：14

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