TICT-based turn-on deep-red fluorescent probe for endoplasmic reticulum targeted detection of serum albumin in kidney diseases

被引：19

作者：

Wang, Hongwei ^{[1
]}

Wang, Jinling ^{[1
]}

Ma, Gang ^{[1
]}

Zhou, Jianjian ^{[1
]}

Du, Longjie ^{[1
]}

Wu, Hanli ^{[2
]}

Zhang, Xiaomeng ^{[1
]}

He, Yongrui ^{[1
]}

Zhou, Jin ^{[1
]}

机构：

[1] Weifang Med Univ, Affiliated Hosp, Sch Clin Med, Sch Pharm, 261031, Weifang 261053, Peoples R China

[2] Yidu Cent Hosp Weifang, Weifang 261000, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2023年 / 464卷

基金：

中国国家自然科学基金;

关键词：

Fluorescent probe; Serum albumin; Acute kidney injury (AKI); Chronic kidney disease (CKD); SELECTIVE DETECTION; LIGAND-BINDING; HSA;

D O I：

10.1016/j.cej.2023.142551

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Serum albumin is an important biomarker of kidney disease, and the rapid and accurate detection of serum albumin is of great significance for clinical diseases, for example, acute kidney injury, chronic kidney disease, and so forth. We designed and synthesized a TICT-based deep-red fluorescent probe that targets endoplasmic reticulum and interacts with serum albumin with good sensing performance. The probe has been successfully applied to the imaging of serum albumin in live cells models of ischemia-reperfusion and nephrotoxic drugs -induced treatment, and more importantly, the probe can quantitatively detect serum albumin in urine sam-ples of rats and human beings with chronic kidney disease by fluorescence method, which is expected to be a promising tool for the diagnosis of kidney disease.

引用

页数：9

共 27 条

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