Role of dendritic cell-derived exosomes in allergic rhinitis (Review)

被引:4
|
作者
Kang, Chenglin [1 ,2 ,3 ,4 ]
He, Haipeng [2 ,3 ]
Liu, Peng [1 ,2 ,3 ]
Liu, Yue [1 ,2 ,3 ]
Li, Xiaomei [4 ]
Zhang, Jin [1 ,2 ,3 ,5 ]
Ran, Hong [1 ,2 ,3 ]
Zeng, Xianhai [1 ,2 ,3 ]
Zhao, Hailiang [1 ,2 ,3 ]
Liu, Jiangqi [1 ,2 ,3 ,6 ,7 ]
Qiu, Shuqi [1 ,2 ,3 ,6 ,7 ]
机构
[1] Zunyi Med Univ Zhuhai Campus, Dept Grad & Sci Res, Zhuhai 519041, Guangdong, Peoples R China
[2] Longgang ENT Hosp, Dept Otolaryngol, Shenzhen 518172, Guangdong, Peoples R China
[3] Inst ENT Shenzhen, Shenzhen Key Lab ENT, Shenzhen 518172, Guangdong, Peoples R China
[4] Second Peoples Hosp Gansu Prov, Dept Otolaryngol, Lanzhou 730000, Gansu, Peoples R China
[5] Second Peoples Hosp Yibin, Dept Otorhinolaryngol, Yibin 644000, Sichuan, Peoples R China
[6] Longgang ENT Hosp, Dept Otolaryngol, 3004 Longgang Ave, Shenzhen 518172, Guangdong, Peoples R China
[7] Inst ENT Shenzhen, Shenzhen Key Lab ENT, 3004 Longgang Ave, Shenzhen 518172, Guangdong, Peoples R China
关键词
dendritic cells; exosomes; extracellular vesicles; intercellular communication; allergic rhinitis; EXTRACELLULAR VESICLES; CANCER-IMMUNOTHERAPY; DELIVERY; BIOLOGY; EFFICIENT; SUBSETS; LIPIDS;
D O I
10.3892/ijmm.2023.5320
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Allergic rhinitis (AR) is a common pathological condition in otorhinolaryngology. Its prevalence has been increasing worldwide and is becoming a major burden to the world population. Dendritic cells (DCs) are typically activated and matured after capturing, phagocytosing, and processing allergens during the immunopathogenesis of AR. In addition, the process of DC activation and maturation is accompanied by the production of exosomes, which are cell-derived extracellular vesicles (EVs) that can carry proteins, lipids, nucleic acids, and other cargoes involved in intercellular communication and material transfer. In particular, DC-derived exosomes (Dex) can participate in allergic immune responses, where the biological substances carried by them can have potentially important implications for both the pathogenesis and treatment of AR. Dex can also be exploited to carry anti-allergy agents to effectively treat AR. This provides a novel method to explore the pathogenesis of and treatment strategies for AR further. Therefore, the present review focuses on the origin, composition, function, and biological characteristics of DCs, exosomes, and Dex, in addition to the possible relationship between Dex and AR.
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收藏
页数:12
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