Access to Chromenopyrrole via Tandem [3+2] Cycloaddition and Intramolecular C-O Coupling

被引：3

作者：

Das, Bubul ^{[1
,2
]}

Chakraborty, Nikita ^{[1
]}

Dhara, Hirendra Nath ^{[1
]}

Bhattacharyya, Pratip ^{[1
]}

Patel, Bhisma K. ^{[1
]}

机构：

[1] Indian Inst Technol Guwahati, Dept Chem, North Guwahati 781039, Assam, India

[2] Assam Engn Coll, Dept Chem, Gauhati 781013, Assam, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 89卷 / 02期

关键词：

MICROTETRASPORA SPIRALIS; BIOSYNTHESIS; PYRALOMICINS; ANTIBIOTICS; PYRROLES;

D O I：

10.1021/acs.joc.3c02479

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and concise method for the synthesis of chromenopyrrole from 2 '-hydroxychalcone is devised. The reaction proceeds via an initial [3 + 2] cycloaddition on the C & boxH;C bond of 2 '-hydroxychalcone and 1,3-dipolarophile, generated in situ by the reaction of ethyl isocyanoacetate and AgOAc. This is then followed by an intramolecular C-O bond formation with the -OH group and C5-H of the in situ generated pyrrole, leading to chromenopyrroles.

引用

页码：1331 / 1335

页数：5

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