Exercise evaluation with metabolic and ventilatory responses and blood lactate concentration in mice

被引:0
|
作者
Yoshikawa, Akira [1 ,2 ,7 ]
Iizuka, Makito [1 ]
Kanamaru, Mitsuko [1 ,3 ]
Kamijo, Shotaro [1 ,4 ]
Ohtaki, Hirokazu [5 ,6 ]
Izumizaki, Masahiko [1 ]
机构
[1] Showa Univ, Sch Med, Dept Physiol, Tokyo, Japan
[2] Showa Univ, Div Hlth Sci Educ, Sch Nursing & Rehabil Sci, Yokohama, Kanagawa, Japan
[3] Showa Univ, Fac Arts & Sci Fujiyoshida, Yamanashi 4030005, Japan
[4] Showa Univ, Sch Pharm, Dept Physiol, Tokyo, Japan
[5] Tokyo Univ Pharm & Life Sci, Sch Pharm, Dept Funct Neurobiol, Hachioji, Tokyo, Japan
[6] Showa Univ, Sch Med, Dept Anat, Tokyo, Japan
[7] Showa Univ, Sch Med, Dept Physiol, 1-5-8 Hatanodai,Shinagawa ku, Tokyo 1428555, Japan
基金
日本学术振兴会;
关键词
Exercise; Evaluation; Age; Pulmonary gas exchange; Ventilatory responses; Lactate; PHYSICAL-ACTIVITY; ANIMAL-MODELS; DYSPNEA PERCEPTION; OXYGEN-CONSUMPTION; STEADY-STATE; INTENSITY; THRESHOLD; RECOMMENDATIONS; DISEASE; STROKE;
D O I
10.1016/j.resp.2023.104163
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
This study aimed to clarify the differential exercise capacity between 2-month-old and 10-month-old mice using an incremental running test. Metabolic and ventilatory responses and blood lactate concentration were measured to evaluate exercise capacity. We examined whether incremental running test results reflected metabolic and ventilatory responses and blood lactate concentration observed during the steady-state running test. Metabolic response significantly declined with age, whereas ventilatory response was similar between the groups. A lowintensity/moderate exercise load of 10/min in an incremental running test was performed on both mice for 30 min. They showed a characteristic pattern in ventilatory response in 10-month mice. The results of incremental running tests didn't necessarily reflect the steady-state metabolic and ventilatory responses because some parameters showed an approximation and others did not in incremental and steady-state tests, which changed with age. Our study suggests metabolic and ventilatory responses depending on age and provides basic knowledge regarding the objective and quantitative assessment of treadmill running in an animal model.
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页数:11
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