Investigation in Hydroxyapatite After Cationic Substitution with Neodymium and Magnesium

The development of biomimetic nanomaterials is paying increasing attention to compositional modeling. Hydroxyapatite is among the essential biomaterials for orthopedic and dental applications because the mineral component of bone is chemically similar to hydroxyapatite-based biomaterials. In this study, hydroxyapatite was cationically substituted with neodymium and magnesium via adopting a wet chemical precipitation technique to produce the analogous inorganic phase of bone and make their structure therapeutically fight pathogens. The morphological and compositional characteristics were tested by utilizing FTIR, XRD, and FESEM which revealed the presence of the HA phase with great compositional purity of the produced nanomaterial and obvious change in crystallinity, lattice properties, morphology, and particle shape. Along with that, the biological tests exhibited improvement in antitumor activity and biocompatibility which were examined with depend on MG63 and WRL68 cell lines, respectively. The presence of neodymium with magnesium in the HA structure makes it has antibacterial and fungicide activity.