Expanding our grasp of two-component signaling in Clostridioides difficile

被引：1
|
作者：
Alvarez, Orlando Berumen [1 ]
Purcell, Erin B. [1 ]
Henkin, Tina M.
机构：
[1] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23508 USA
来源：
JOURNAL OF BACTERIOLOGY | 2023年 / 205卷 / 10期
基金：
美国国家科学基金会;
关键词：
Clostridioides difficile; two-component signaling; LOCUS; GENE;
D O I：
10.1128/jb.00188-23
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The intestinal pathogen Clostridioides difficile encodes roughly 50 TCS, but very few have been characterized in terms of their activating signals or their regulatory roles. A. G. Pannullo, B. R. Zbylicki, and C. D. Ellermeier (J Bacteriol 205:e00164-23, 2023, https://doi.org/10.1128/jb.00164-23) have identified both for the novel C. difficile TCD DraRS. DraRS responds to antibiotics that target lipid-II molecules in the bacterial cell envelope, and regulates the production of a novel glycolipid necessary for bacitracin and daptomycin resistance in C. difficile.
引用
收藏
页数：7
相关论文
共 50 条
  • [31] A Case for Two-Component Signaling Systems As Antifungal Drug Targets
    Shor, Erika
    Chauhan, Neeraj
    PLOS PATHOGENS, 2015, 11 (02)
  • [32] The Interaction Network and Signaling Specificity of Two-Component System inArabidopsis
    Huo, Ruxue
    Liu, Zhenning
    Yu, Xiaolin
    Li, Zongyun
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (14) : 1 - 23
  • [33] Involvement of Two-Component Signaling on Bacterial Motility and Biofilm Development
    Pruss, Birgit M.
    JOURNAL OF BACTERIOLOGY, 2017, 199 (18)
  • [34] Structures and molecular recognition of two-component signaling proteins in plant
    Sugawara, H
    Yamaya, T
    Sakakibara, H
    PLANT AND CELL PHYSIOLOGY, 2003, 44 : S22 - S22
  • [35] Expanding the repertoire of conservative site-specific recombination in Clostridioides difficile
    Sekulovic, Ognjen
    Bourgeois, Jacob
    Shen, Aimee
    Camilli, Andrew
    ANAEROBE, 2019, 60
  • [36] Clostridium difficile and Clostridioides difficile: Two validly published and correct names
    Oren, Aharon
    Rupnik, Maja
    ANAEROBE, 2018, 52 : 125 - 126
  • [37] Two-component injection
    Modern Plastics, 1993, 70 (06):
  • [38] Two-component oscillator
    Abuelma'atti, MT
    Buhalim, SS
    ELECTRONICS WORLD, 1996, 102 (1724): : 615 - 615
  • [39] Two-Component Immunization
    Kolesin, Igor
    2017 CONSTRUCTIVE NONSMOOTH ANALYSIS AND RELATED TOPICS (DEDICATED TO THE MEMORY OF V.F. DEMYANOV) (CNSA), 2017, : 156 - 157
  • [40] Two-component epoxy
    Mandelis, Andreas
    REVIEW OF SCIENTIFIC INSTRUMENTS, 2014, 85 (09):
12345