Inhibition of Galectins and the P2X7 Purinergic Receptor as a Therapeutic Approach in the Neurovascular Inflammation of Diabetic Retinopathy

被引：4

作者：

Lepre, Caterina Claudia ^{[1
]}

Russo, Marina ^{[2
]}

Trotta, Maria Consiglia ^{[2
]}

Petrillo, Francesco ^{[3
]}

D'Agostino, Fabiana Anna ^{[4
]}

Gaudino, Gennaro ^{[5
]}

D'Amico, Giovanbattista ^{[6
]}

Campitiello, Maria Rosaria ^{[7
,8
]}

Crisci, Erminia ^{[4
]}

Nicoletti, Maddalena ^{[4
]}

Gesualdo, Carlo ^{[4
]}

Simonelli, Francesca ^{[4
]}

D'Amico, Michele ^{[2
]}

Hermenean, Anca ^{[1
]}

Rossi, Settimio ^{[4
]}

机构：

[1] Vasile Goldis Western Univ Arad, Aurel Ardelean Inst Life Sci, Arad 310144, Romania

[2] Univ Campania Luigi Vanvitelli, Dept Expt Med, I-80138 Naples, Italy

[3] Univ Campania Luigi Vanvitelli, Dept Expt Med, Course Translat Med, I-80138 Naples, Italy

[4] Univ Campania Luigi Vanvitelli, Multidisciplinary Dept Med, Surg & Dent Sci, I-80138 Naples, Italy

[5] Univ Foggia, Sch Anesthesia & Intens Care, I-71122 Foggia, Italy

[6] Univ Studies Aquila, Sch Geriatr, I-67010 Laquila, Italy

[7] ASL Salerno, Dept Obstet & Gynecol, I-84124 Salerno, Italy

[8] ASL Salerno, Dept Physiopathol Human Reprod, I-84124 Salerno, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 11期

关键词：

diabetic retinopathy; neuroinflammation; ROS; ER stress; NLRP3; inflammasome; galectins; P2X7R; CENTRAL-NERVOUS-SYSTEM; OXIDATIVE STRESS; MOUSE MODEL; P2X(7) RECEPTOR; RETINAL MICROGLIA; EPITHELIAL-CELLS; MACULAR EDEMA; MULLER CELLS; ACTIVATION; NLRP3;

D O I：

10.3390/ijms24119721

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetic retinopathy (DR) is the most frequent microvascular retinal complication of diabetic patients, contributing to loss of vision. Recently, retinal neuroinflammation and neurodegeneration have emerged as key players in DR progression, and therefore, this review examines the neuroinflammatory molecular basis of DR. We focus on four important aspects of retinal neuroinflammation: (i) the exacerbation of endoplasmic reticulum (ER) stress; (ii) the activation of the NLRP3 inflammasome; (iii) the role of galectins; and (iv) the activation of purinergic 2X7 receptor (P2X7R). Moreover, this review proposes the selective inhibition of galectins and the P2X7R as a potential pharmacological approach to prevent the progression of DR.

引用

页数：20

共 50 条

[21] The role of the purinergic receptor p2x7 in the pathogenesis of atherosclerosis
Merz, J.
Heidenreich, A.
Stachon, P.
Bode, C.
Zirlik, A.
EUROPEAN HEART JOURNAL, 2017, 38 : 853 - 853
[22] The P2X7 receptor as a therapeutic target
Romagnoli, Romeo
Baraldi, Pier Giovanni
Cruz-Lopez, Olga
Lopez-Cara, Carlota
Preti, Delia
Borea, Pier Andrea
Gessi, Stefania
EXPERT OPINION ON THERAPEUTIC TARGETS, 2008, 12 (05) : 647 - 661
[23] P2X7 Receptor as a Therapeutic Target
De Marchi, Elena
Orioli, Elisa
Dal Ben, Diego
Adinolfi, Elena
ION CHANNELS AS THERAPEUTIC TARGETS, PT B, 2016, 104 : 39 - 79
[24] Role of Purinergic P2X7 Receptors in Allergic Inflammation.
Faffe, D. S.
Costa-Vieira, J.
Mazzoli-Rocha, F.
Cagido, V. R.
Moncao-Ribeiro, L. C.
Takiya, C. M.
Coutinho-Silva, R.
Zin, W. A.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 179
[25] Structure-Activity Relationships and Therapeutic Potential of Purinergic P2X7 Receptor Antagonists
El Idrissi, Imane Ghafir
Podlewska, Sabina
Abate, Carmen
Bojarski, Andrzej J.
Lacivita, Enza
Leopoldo, Marcello
CURRENT MEDICINAL CHEMISTRY, 2024, 31 (11) : 1361 - 1403
[26] Role of P2X7 receptors in the development of diabetic retinopathy
Sugiyama, Tetsuya
WORLD JOURNAL OF DIABETES, 2014, 5 (02): : 141 - 145
[27] Interaction of Purinergic P2X4 and P2X7 Receptor Subunits
Markwardt, Fritz
Schneider, Markus
Prudic, Kirsten
Pippel, Anja
Klapperstueck, Manuela
Mueller, Christa
Stolz, Michaela
Schumacher, Michaela
Schmalzing, Gunther
BIOPHYSICAL JOURNAL, 2017, 112 (03) : 421A - 421A
[28] Interaction of Purinergic P2X4 and P2X7 Receptor Subunits
Schneider, Markus
Prudic, Kirsten
Pippel, Anja
Klapperstueck, Manuela
Braam, Ursula
Mueller, Christa E.
Schmalzing, Guenther
Markwardt, Fritz
FRONTIERS IN PHARMACOLOGY, 2017, 8
[29] The purinergic P2X7 ion channel receptor - a 'repair' receptor in bone
Jorgensen, Niklas Rye
CURRENT OPINION IN IMMUNOLOGY, 2018, 52 : 32 - 38
[30] The P2X7 purinergic receptor as a molecular target in bipolar disorder
Gubert, Carolina
Fries, Gabriel Rodrigo
de Aguiar, Bianca Wollenhaupt
Rosa, Adriane Ribeiro
Busnello, Joao Vicente
Ribeiro, Luciana
Morrone, Fernanda Bueno
Oliveira Battastini, Ana Maria
Kapczinski, Flavio
NEUROPSYCHIATRIA I NEUROPSYCHOLOGIA, 2013, 8 (01): : 1 - 7

← 1 2 3 4 5 →