Biological characteristics of γδT cells and application in tumor immunotherapy

被引：6
|
作者：
Zhu, Renhong [1 ,2 ]
Yan, Qian [3 ]
Wang, Yashu [4 ]
Wang, Keqiang [1 ]
机构：
[1] Shandong First Med Univ, Dept Lab Med, Affiliated Hosp 2, Tai An, Peoples R China
[2] Taian Tumor Prevent & Treatment Hosp, Dept Lab Med, Tai An, Peoples R China
[3] Second Hosp Tradit Chinese Med, Dept Lab Med, Tai An, Peoples R China
[4] Qingdao Univ, Dept Lab Med, Affiliated Taian City Cent Hosp, Tai An, Peoples R China
来源：
FRONTIERS IN GENETICS | 2023年 / 13卷
基金：
中国国家自然科学基金;
关键词：
gamma delta T cells; tumor; immunotherapy; progress; biological; BISPHOSPHONATE ZOLEDRONIC ACID; HUMAN NATURAL-KILLER; STEM-LIKE CELLS; ALPHA-BETA; PERIPHERAL-BLOOD; ADOPTIVE IMMUNOTHERAPY; HEPATOCELLULAR-CARCINOMA; CELLULAR IMMUNOTHERAPY; CHEMOTHERAPY IMPROVES; DENDRITIC CELLS;
D O I：
10.3389/fgene.2022.1077419
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Human gamma delta T cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex (MHC)-restricted immune response. They play an important role in the body's anti-tumor, anti-infection, immune regulation, immune surveillance and maintenance of immune tolerance. This article reviews the generation and development of human gamma delta T cells, genetic characteristics, classification, recognition and role of antigens, and research progress in tumor immunotherapy.
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页数：14
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