Design and Synthesis of Bicyclo[4.3.0]nonene Nucleoside Analogues

被引：0

作者：

Scheeff, Stephan ^{[1
]}

Wang, Yan ^{[2
,5
]}

Lyu, Mao-Yun ^{[1
]}

Ahmadabadi, Behzad Nasiri ^{[2
,5
]}

Hau, Sam Chun Kit ^{[3
]}

Hui, Tony K. C. ^{[4
]}

Zhang, Yufeng ^{[1
]}

Zuo, Zhong ^{[1
]}

Chan, Renee Wan Yi ^{[2
,5
,6
,7
]}

Ng, Billy Wai-Lung ^{[1
,6
]}

机构：

[1] Chinese Univ Hong Kong, Fac Med, Sch Pharm, Shatin, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Dept Paediat, Shatin, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China

[4] Primemax Biotech Ltd, Shatin, Hong Kong, Peoples R China

[5] Chinese Univ Hong Kong, Hong Kong Hub Paediat Excellence, Kowloon Bay, Hong Kong, Peoples R China

[6] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Fac Med, Shatin, Hong Kong, Peoples R China

[7] Chinese Univ Hong Kong, Fac Med, SH Ho Res Ctr Infect Dis, Shatin, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 50期

关键词：

DIELS-ALDER REACTIONS; CARBOCYCLIC NUCLEOSIDES; SUGAR RING; POTENT; DISCOVERY; CRYSTAL; FORMS;

D O I：

10.1021/acs.orglett.3c03590

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleoside analogues are effective antiviral agents, and the continuous emergence of pathogenic viruses demands the development of novel and structurally diverse analogues. Here, we present the design and synthesis of novel nucleoside analogues with a carbobicyclic core, which mimics the conformation of natural ribonucleosides. Employing a divergent synthetic route featuring an intermolecular Diels-Alder reaction, we successfully synthesized carbobicyclic nucleoside analogues with high antiviral efficacy against respiratory syncytial virus.

引用

页码：9002 / 9007

页数：6

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