KF-catalyzed direct thiomethylation of carboxylic acids with DMSO to access methyl thioesters

With dimethyl sulfoxide (DMSO) as the methylthio source, a KF-catalyzed strategy was employed for the direct thiomethylation of carboxylic acids with DMSO for the preparation of methyl thioesters. In this process, a wide range of methyl thioesters were obtained in moderate to excellent yields. This novel strategy features the first use of DMSO as a methylthiolating agent for the construction of methyl thioesters, transition metal-free conditions, inexpensive reagents, easy workup, broad substrate scope and sustainability. Additionally, this procedure can be readily scaled up to a gram scale. A transition metal-free, KF-catalyzed synthesis of methyl thioesters has been developed via the direct thiomethylation of carboxylic acids with DMSO.