The Construction of Polycyclic Pyridones via Ring-Opening Transformations of 3-hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-diones

被引：6

作者：

Viktorova, Viktoria V. ^{[1
]}

Steparuk, Elena V. ^{[1
]}

Obydennov, Dmitrii L. ^{[1
]}

Sosnovskikh, Vyacheslav Y. ^{[1
]}

机构：

[1] Ural Fed Univ, Inst Nat Sci & Math, 51 Lenina Ave, Ekaterinburg 620000, Russia

来源：

MOLECULES | 2023年 / 28卷 / 03期

关键词：

4-pyridone; oxazinone; ring-opening; benzimidazole; aldehyde-lactol tautomerism; ammonium acetate; ETHYL; 5-ACYL-4-PYRONE-2-CARBOXYLATES; FINAL FORMS; DOLUTEGRAVIR; EFFICIENT; 6-ARYL; ACIDS;

D O I：

10.3390/molecules28031285

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This work describes the synthesis of 3-hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-diones, their tautomerism, and reactivity towards binucleophiles. These molecules are novel and convenient building-blocks for the direct construction of biologically important polycyclic pyridones via an oxazinone ring-opening transformation promoted with ammonium acetate or acetic acid. In the case of o-phenylenediamine, partial aromatization of the obtained heterocycles proceeded to form polycyclic benzimidazole-fused pyridones (33-91%).

引用

页数：13

共 15 条

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