A new and novel amide bond cleavage of N-methoxymethyl-pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones by hydride reduction via 3-aza-Grob fragmentation

被引：8
|
作者：
Wang, JJ [1 ]
Hu, WP
Chung, HW
Wang, LF
Hsu, MH
机构：
[1] Kaohsiung Med Coll, Sch Chem, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Coll, Grad Inst Natl Prod, Kaohsiung 807, Taiwan
[3] Kaohsiung Med Coll, Grad Inst Pharmaceut Sci, Kaohsiung 807, Taiwan
来源：
TETRAHEDRON | 1998年 / 54卷 / 43期
关键词：
D O I：
10.1016/S0040-4020(98)00795-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel amide bond cleavage of N-methoxymethylpyrrolo[2, 1-c][1,4]benzodiazepine-5, 1 l-diones by hydride reduction in high yield is described. MOM-protected dilactams 1 undergo ring-opening when treated with metal hydride via 3-aza-Grob fragmentation. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：13149 / 13154
页数：6
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