Analysis of Fluorescence Collection Efficiency for Fiber-optic Scanning Two-photon Endomicroscopy

被引：0
|
作者：
Wang, Conghao [1 ]
Liu, Huilan [1 ,2 ]
Wang, Aimin [3 ]
Feng, Lishuang [1 ,2 ,4 ]
机构：
[1] Beihang Univ, Sch Instrumentat & Optoelect Engn, Beijing 100191, Peoples R China
[2] Minist Educ, Key Lab Precis Opto Mechatron Technol, Beijing 100191, Peoples R China
[3] Peking Univ, Sch Elect, State Key Lab Adv Opt Commun Syst & Networks, Beijing 100871, Peoples R China
[4] Beihang Univ, Hangzhou Innovat Inst, Lab Intelligent Sensing Mat & Chip Integrat Techn, Hangzhou 310063, Peoples R China
来源：
SPIE-CLP CONFERENCE ON ADVANCED PHOTONICS 2022 | 2023年 / 12601卷
关键词：
two-photon endomicroscopy; collection efficiency; double-cladding fiber; piezoelectric ceramic scanning; MICROSCOPY;
D O I：
10.1117/12.2667161
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Piezoelectric ceramic tube fiber-scanning two-photon endomicroscopy is an essential division of miniature two-photon microscopy. The reverse collection optical path of the two-photon endomicroscopy platform is modeled and designed in this study. After simulating the chromatic aberration characteristics of the objective, the effects of the collection signal wavelengths, off-axis positions, fiber cladding diameters, and imaging depths on the collection efficiency are evaluated using Monte Carlo simulation. The results provide an additional theoretical explanation for enhancing the two-photon endomicroscopy platform's imaging sensitivity and signal-to-noise ratio.
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页数：5
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