Preclinical development of ADCT-211, a novel pyrrolobenzodiazepine dimer-based antibody-drug conjugate targeting solid tumors expressing IL13RA2

被引：0
|
作者：
Zammarchi, Francesca
Havenith, Karin
Leatherdale, Ben
Roberts, Britanny
Montolio, Lara
Patel, Afroze
Janghra, Narinder
Alves, Pedro
Zaitseva, Kristina
Kirby, Cecile Oblette Ian
de Haan, Lolke
van Berkel, Patrick H.
机构：
来源：
CANCER RESEARCH | 2023年 / 83卷 / 07期
关键词：
D O I：
10.1158/1538-7445.AM2023-1604
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1604
引用
收藏
页数：3
相关论文
共 43 条
  • [21] Preclinical development of a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer
    Son, Thomas
    Scribner, Juniper A.
    Hooley, Jeff
    Chiechi, Michael
    Li, Pam
    Hotaling, Timothy E.
    De Costa, Anushka
    Chen, Yan
    Chen, Francine
    Barat, Bhaswati
    Ciccarone, Valentina
    Gaynutdinov, Timur
    Tamura, James
    Koenig, Scott
    Johnson, Syd
    Moore, Paul A.
    Bonvini, Ezio
    Loo, Deryk
    CANCER RESEARCH, 2017, 77
  • [22] Preclinical development of YL202, a novel HER3-targeting antibody-drug conjugate (ADC) with novel DNA topoisomerase I inhibitor for treatment of solid tumors
    Xu, Jian
    Zong, Qing
    Zhu, Liang
    Liu, Qigang
    Stann, Sasha
    Cai, Jiaqiang
    CANCER RESEARCH, 2023, 83 (07)
  • [23] Preclinical efficacy studies using HuMax-Axl-ADC, a novel antibody-drug conjugate targeting Axl-expressing solid cancers.
    Breij, Esther C. W.
    Verploegen, Sandra
    Lingnau, Andreas
    van den Brink, Edward N.
    Janmaat, Maarten
    Houtkamp, Mischa
    Bleeker, Wim
    Satijn, David
    Parren, Paul
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (15)
  • [24] Preclinical radiolabeling, in vivo biodistribution and positron emission tomography of a novel pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2
    Wichmann, Christian Werner
    Burvenich, Ingrid Julienne Georgette
    Guo, Nancy
    Rigopoulos, Angela
    McDonald, Alexander
    Cao, Diana
    O'Keefe, Graeme Joseph
    Gong, Sylvia Jie
    Gan, Hui Kong
    Scott, Fiona Elizabeth
    Pore, Nabendu
    Coats, Steven
    Scott, Andrew Mark
    NUCLEAR MEDICINE AND BIOLOGY, 2023, 122
  • [25] Preclinical development of YL205, a novel NaPi2b-targeting antibody-drug conjugate (ADC) with novel topoisomerase I inhibitor-based linker- payload for treatment of solid tumors
    Xiao, Liang
    Lian, Wei
    Liu, Qigang
    Zong, Qing
    Song, Shuai
    Stann, Sasha
    Cai, Jiaqiang
    Xue, Tongtong
    CANCER RESEARCH, 2024, 84 (06)
  • [26] Discovery and development of MEDI7247, a novel Pyrrolobenzodiazepine (PBD)-based antibody drug conjugate targeting ASCT2, treating hematological and solid cancers
    Pore, Nabendu
    Borrok, M. Jack
    Rebellato, Marlon
    Hinrichs, MaryJane
    Schifferli, Kevin P.
    Monks, Noel R.
    Tammali, Ravinder
    Herbst, Ronald
    Coats, Steven R.
    Tice, David A.
    CANCER RESEARCH, 2018, 78 (13)
  • [27] hLL2-Cys-PBD, a New Site-Specifically Conjugated, Pyrrolobenzodiazepine (PBD) Dimer-Based Antibody Drug Conjugate (ADC) Targeting CD22-Expressing B-Cell Malignancies.
    Zammarchi, Francesca
    Corbett, Simon
    Adams, Lauren
    Mellinas-Gomez, Maria
    Tyrer, Peter
    Dissanayake, Sandamali
    Sims, Simone
    Havenith, Karin
    Chivers, Simon
    Willimas, David G.
    Howard, Philip W.
    Hartley, John A.
    van Berkel, Patrick
    BLOOD, 2016, 128 (22)
  • [28] Preclinical Evaluation of IMGC936, a Next-Generation Maytansinoid-based Antibody-drug Conjugate Targeting ADAM9-expressing Tumors
    Scribner, Juniper A.
    Hicks, Stuart W.
    Sinkevicius, Kerstin W.
    Yoder, Nicholas C.
    Diedrich, Gundo
    Brown, Jennifer G.
    Lucas, Jacquelynn
    Fuller, Megan E.
    Son, Thomas
    Dastur, Anahita
    Hooley, Jeff
    Espelin, Christopher
    Themeles, Marian
    Chen, Francine Z.
    Li, Ying
    Chiechi, Michael
    Lee, Jenny
    Barat, Bhaswati
    Widjaja, Lusiana
    Gorlatov, Sergey
    Tamura, James
    Ciccarone, Valentina
    Ab, Olga
    McEachem, Kerry A.
    Koenig, Scott
    Westin, Eric H.
    Moore, Paul A.
    Chittenden, Thomas
    Gregory, Richard J.
    Bonvini, Ezio
    Loo, Deryk
    MOLECULAR CANCER THERAPEUTICS, 2022, 21 (07) : 1047 - 1059
  • [29] Preclinical Efficacy of the Auristatin-Based Antibody-Drug Conjugate BAY 1187982 for the Treatment of FGFR2-Positive Solid Tumors
    Sommer, Anette
    Kopitz, Charlotte
    Schatz, Christoph A.
    Nising, Carl F.
    Mahlert, Christoph
    Lerchen, Hans-Georg
    Stelte-Ludwig, Beatrix
    Hammer, Stefanie
    Greven, Simone
    Schuhmacher, Joachim
    Braun, Manuela
    Zierz, Ruprecht
    Wittemer-Rump, Sabine
    Harrenga, Axel
    Dittmer, Frank
    Reetz, Frank
    Apeler, Heiner
    Jautelat, Rolf
    Huynh, Hung
    Ziegelbauer, Karl
    Kreft, Bertolt
    CANCER RESEARCH, 2016, 76 (21) : 6331 - 6339
  • [30] Preclinical development of MGC018, a duocarmycin-based antibody-drug conjugate targeting B7-H3 for solid cancer
    Scribner, Juniper A.
    Brown, Jennifer G.
    Sharma, Sharad
    Li, Hua
    Chiechi, Michael
    Li, Pam
    Son, Thomas
    De Costa, Anushka
    Chen, Yan
    Chen, Francine
    Barat, Bhaswati
    Huang, Ling
    Wolff, Christina
    Hooley, Jeff
    Hotaling, Tim E.
    Gaynutdinov, Timur
    Ciccarone, Valentina
    Tamura, James
    Koenig, Scott
    Johnson, Syd
    Moore, Paul A.
    Bonvini, Ezio
    Loo, Deryk
    CANCER RESEARCH, 2018, 78 (13)
12345